摘要
目的:观察达络肺仙饮治疗特发性肺纤维化的疗效,并探讨其作用机制。方法:将100例特发性肺纤维化患者以随机数字表法分为观察组和对照组各50例,对照组接受常规西医治疗,观察组在此基础上服用达络肺仙饮治疗;治疗前、后检测两组患者血清微RNA-29b、NOD样受体热蛋白结构域相关蛋白3(NLRP3)、色素上皮衍生因子(PEDF)、肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白(HMGB1)、血管内皮生长因子(VEGF)、缺氧诱导因子-1α(HIF-1α)、白细胞介素-8(IL-8)、胰岛素样生长因子结合蛋白-5(IGFBP-5)、潜在转化生长因子结合蛋白2(LTBP2)、透明质酸(HA)水平;检测两组患者肺功能:肺总量占预计值百分比(TLC%pred)、最大呼气中段流量(MMF)、肺一氧化碳弥散量(DLCO)、用力肺活量(FVC);治疗前、后给予患者高分辨CT(HRCT)评价及6 min步行距离(6MWT)检测,比较两组临床疗效。结果:治疗后,以上血清学指标,两组均较治疗前改善(P<0.05),且观察组较对照组改善更明显(P<0.05);治疗后,两组肺功能水平均较治疗前升高(P<0.05),且观察组高于对照组(P<0.05);治疗后,两组6MWT均较治疗前增加(P<0.05),且观察组多于较对照组(P<0.05);治疗后,两组HRCT评分均降低(P<0.05),且观察组低于对照组(P<0.05);总有效率观察组97.87%,对照组89.58%,观察组疗效优于对照组(P<0.05)。结论:达络肺仙饮治疗特发性肺纤维化,可减轻机体炎症反应,抑制微血管产生及肺纤维化,改善患者肺功能及活动能力,提高临床疗效。
Objective:To observe the therapeutic effect of Daluo Feixian Decoction(达络肺仙饮)on idiopathic pulmonary fibrosis and explore its mechanism.Methods:A total of 100 patients with idiopathic pulmonary fibrosis were divided into observation group and control group by random number table method.The patients in control group were given conventional western medicine treatment,and the patients in observation group were given Daluo Feixian Decoction on the basis of conventional western medicine treatment.Serum micrornA-29b,Nod-like receptor heat protein domain associated protein 3(NLRP3),pigment epithelite-derived factor(PEDF),tumor necrosis factor-α(TNF-α),high mobility group box 1 protein(HMGB1),vascular endothelial growth factor(VEGF),hypoxia-inducing factor-1α(HIF-1α),interleukin-8(IL-8),insulin-like growth factor binding protein-5(IGFBP-5),potentially transforming growth factor binding protein 2(LTBP2),and hyaluronic acid(HA)levels were detected in two groups before and after treatment.The pulmonary function of the two groups were detected:percentage of total lung to the expected value(TLC%pred),maximum mid-expiratory flow(MMF),diffusing capacity of the lung for Carbon Monoxide(DLCO),forced vital capacity(FVC).Before and after treatment,the patients were evaluated by high-resolution CT(HRCT)and measured by 6-min walking distance(6MWT).The clinical efficacy of the two groups was compared.Results:After treatment,the above serological indexes were improved in both groups compared with before treatment(P<0.05),and the improvement in observation group was more obvious than control group(P<0.05).The level of lung function in both groups was higher than before treatment(P<0.05),and the observation group was higher than the control group(P<0.05).6MWT increased in both groups compared with before treatment(P<0.05),and the observation group was more than the control group(P<0.05).The HRCT scores of both groups were decreased(P<0.05),and the observation group was lower than the control group(P<0.05).The total effective rate of the observation group was 97.87%and that of the control group was 89.58%.The curative effect of the observation group was better than that of the control group(P<0.05).Conclusion:Daluo Feixian Decoction in the treatment of idiopathic pulmonary fibrosis can reduce inflammation,inhibit microvascular production and pulmonary fibrosis,improve lung function and activity,and improve clinical efficacy.
作者
王国梁
杨华
孙丽凤
宋晓栋
亓晓
刘颖
WANG Guoliang;YANG Hua;SUN Lifeng;SONG Xiaodong;QI Xiao;LIU Ying(Pulmonary Disease Department,Yantai Traditional Chinese Medicine Hospital,Yantai 264013,China;Internal Medicine Department,Yantai Municipal Government Hospital,Yantai 264013,China)
出处
《山东中医杂志》
2023年第6期564-569,582,共7页
Shandong Journal of Traditional Chinese Medicine
基金
国家卫生发展科研专项项目(编号:22-5-3-10-YHC)。
关键词
达络肺仙饮
特发性肺纤维化
炎症反应
微血管
肺功能
Daluo Feixian Decoction
idiopathic pulmonary fibrosis
inflammation
microvessel
lung function
作者简介
王国梁(1988-),男,山东淄博人,医学硕士,主治医师,主要从事中西医结合治疗肺系疾病研究。电话:18765079983,邮箱:slunqanu111@126.com;通信作者:孙丽凤(1971-),女,山东烟台人,硕士研究生导师,主任医师,主要从事中医药治疗肺系疾病的研究。邮箱:sunlifeng@126.com。
