摘要
特发性肺纤维化(Idiopathic pulmonary fibrosis,IPF)是一种慢性致死性间质性肺疾病,严重威胁人类健康与生命,目前除肺移植外尚无特效治疗方法。中医理论认为气虚血瘀是IPF的关键病机,故将益气活血法确立为治疗IPF的重要方法。研究发现益气活血类方药在改善IPF患者的临床症状和延缓疾病进展方面具有确切疗效。基于其临床有效性,近年来围绕益气活血法治疗IPF的相关机制进行了大量研究,本文通过查阅相关文献,从抑制炎症反应、改善细胞外基质代谢、干预上皮/内皮间质转化、抗氧化应激、减少血管新生、激活细胞自噬、调节免疫平衡、调控纤溶活性等方面对益气活血法治疗IPF的作用机制进行综述,从而揭示益气活血法治疗IPF的科学内涵,为临床运用益气活血法治疗IPF提供理论依据。
Idiopathic pulmonary fibrosis(IPF)is a chronic and fatal interstitial lung disease that poses a serious threat to human health and life,and currently there is no specific treatment for it except lung transplantation.The theory of traditional Chinese medicine(TCM)holds that Qi deficiency and blood stasis are the critical pathogenesis of IPF,so the therapy of invigorating Qi and activating blood circulation is established as the important method for the treatment of IPF.Studies have found that the prescriptions for invigorating Qi and activating blood have definite efficacy in improving the clinical symptoms of patients with IPF and delaying the progression of the disease.Based on its clinical effectiveness,a large number of researches have been carried out on the relevant mechanism of invigorating Qi and activating blood circulation in the treatment of IPF in recent years.In this paper,we systematically reviewed the relevant literature,and made a review on the mechanism of Qi-invigorating and blood-activating therapy in the treatment of IPF from the aspects inhibiting inflammation,improving the metabolism of extracellular matrix,intervening epithelial/endothelial-mesenchymal transformation,resisting oxidative stress,reducing angiogenesis,activating cellular autophagy,regulating immune balance and fibrinolytic activity,so as to reveal the scientific connotation of Qi-invigorating and blood-activating therapy and provide a theoretical basis for the clinical application of this therapy in the treatment of IPF.
作者
安丽萍
杜全宇
杨晗
王飞
An Liping;Du Quanyu;Yang Han;Wang Fei(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第6期2122-2131,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会青年科学基金项目(82104829):基于LINC00271/SREBP1/ACC信号轴研究补阳还五汤调节脂代谢依赖性内皮-间质转化干预肺纤维化的机制,负责人:杜全宇
中国博士后科学基金会面上项目(2020M683644XB):基于IncRNA TCF4-AS1/TCF4/Vimentin信号轴研究补阳还五汤调控糖尿病肺纤维化EndMT的分子机制,负责人:杜全宇
四川省中医药管理局科学技术研究专项(2020JC0049):补阳还五汤介导miR21调控肺纤维化自噬缺失的机制研究,负责人:杨晗。
关键词
特发性肺纤维化
益气活血法
气虚血瘀
作用机制
研究进展
Idiopathic pulmonary fibrosis
Invigorating qi and activating blood circulation
Qi deficiency and blood stasis
Mechanism of action
Research progress
作者简介
通讯作者:王飞,教授,博士生导师,主要研究方向:中医药防治呼吸病和老年病的临床与基础研究。
