摘要
白细胞介素-6(IL-6)作为一种由多种细胞产生的多效细胞因子,在临床上与感染性疾病、代谢性疾病以及慢性炎症等疾病的发生、发展和预后密切相关。针对不同疾病,IL-6的信号通路不完全相同,相对应的作用特点、相关治疗方式也不尽相同。大量动物实验以及临床研究表明,及时监测血液中IL-6的浓度变化有利于对疾病做出准确判断。文章主要对IL-6在临床常见疾病中的作用机制、作用效果、影响因素、以及靶向阻断IL-6的相关治疗方式的研究进展进行总结,旨在为临床及相关研究提供参考。
Interleukin-6(IL-6),as a pleiotropic cytokine produced by a variety of cells,is clinically closely related to the occurrence,development and prognosis of infectious diseases,metabolic diseases and chronic inflammation.For different diseases,the signaling pathway of IL-6 is not completely the same,and the corresponding action characteristics and related treatment methods are also different.A large number of animal experiments and clinical studies have shown that timely monitoring of the concentration of IL-6 in blood is conducive to making an accurate judgment of disease.This article mainly summarizes the research progress of the mechanism,effect and influencing factors of IL-6 in common clinical diseases,as well as the related treatment methods for IL 6 blockade,so as to provide reference for clinical and related research.
作者
张锦鹏
王颢典
任华建(综述)
任建安(审校)
ZHANG Jinpeng;WANG Haodian;REN Huajian;REN Jian′an(Research Institute of General Surgery,Affiliated Hospital of Medical School,Nanjing University/General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China;Brigade of Cadet the Third Military Medical University,Chongqing 400000,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2023年第2期196-201,共6页
Journal of Medical Research & Combat Trauma Care
基金
江苏省重点研发计划(BE2022823)。
作者简介
通信作者:任建安,E-mail:jiananr@nju.edu.cn。
