摘要
COVID-19是由新型冠状病毒引起的一种急性传染性疾病,全身炎症反应是其重要的致病机制之一。补体作为固有免疫系统的重要组分,在机体抗感染的炎症防御反应中发挥关键作用。补体过度激活导致的炎症风暴在COVID-19发病过程中具有重要影响,靶向阻断或调控补体的级联反应对COVID-19患者具有一定的治疗作用。本文将对补体系统在COVID-19发病及进展中的作用做一综述。
COVID-19 is a highly contagious disease caused by SARS-CoV-2 infection.Systemic inflammatory response is one of the crucial pathogenic mechanisms.As a key component of the innate immune system,the complement system can quickly provoke an inflammatory reaction against infectious pathogens,serving as a defense mechanism of the body.Studies have showed that the inflammatory storm caused by over-activation of the complement plays a critical role in the development of COVID-19,and blocking or regulating the complement cascade has a certain therapeutic effect on patients with COVID-19.In this review,the roles of the complement system in the pathogenesis and development of COVID-19 were summarized.
作者
王稳
马海军
郭明好
Wang Wen;Ma Haijun;Guo Minghao(Department of Rheumatology and Immunology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2023年第3期239-242,共4页
Chinese Journal of Microbiology and Immunology
基金
河南省重点研发与推广专项科技攻关项目(212102310763)
河南省高等学校重点科研项目(20B320015)
新型冠状病毒防控应急科研攻关项目(20GG009)。
作者简介
通信作者:马海军,Email:haijunma97@hotmail.com,电话:0373-4402183。
