摘要
肠易激综合征(IBS)是一种功能性胃肠病,但常引起胃肠极度不适且病情迁延,严重影响患者的生活质量,全球发病率逐年上升。临床上,西医主要予以口服解痉、促泌、抗抑郁类药物等治疗,但存在不良反应多,远期疗效差等弊端,因此,寻找高效安全的治疗方法是亟需解决的问题。大量研究表明,中医药治疗IBS疗效确切、作用持久,成为了近年研究的热点方向。通过检索国内外文献发现,中医药方法治疗IBS相关通路的机制研究中,以电针、艾灸、中药单体、复方汤剂为主,作用途径涉及核转录因子-κB(NF-κB)、瞬时受体电位香草酸亚型1(TRPV1)、5-羟色胺(5-HT)、丝裂原活化蛋白激酶(MAPK)等多条信号通路。中医药能通过调节此系列信号通路修复肠道炎症、降低内脏敏感性、增强肠黏膜屏障及调节肠道动力,发挥着多层次、多环节、多靶点治疗IBS的重要作用。该文以细胞信号通路为基础,综述中医药治疗IBS机制研究的进展,以期为临床上中医药治疗IBS提供理论支撑和诊疗思路。
Irritable bowel syndrome(IBS)is a functional gastrointestinal disease,but it often causes extreme gastrointestinal discomfort and prolonged illness,which seriously affects the quality of life of patients.The global incidence rate is increasing year by year.Clinically,western medicine mainly uses oral antispasmodics,secretagogues,and antidepressants,but there are many disadvantages such as adverse reactions and poor long-term efficacy.Therefore,finding an efficient and safe treatment method is an urgent problem to be solved.A large number of studies have shown that traditional Chinese medicine has definite curative and long-lasting effects on the treatment of IBS,which has become a hot research direction in recent years.By searching Chinese and foreign literature,it is found that electroacupuncture,moxibustion,Chinese medicine monomers,and compound decoctions are the main methods in the mechanism research of traditional Chinese medicine in the treatment of IBS-related pathways,and their signaling pathways involve nuclear transcription factor kappa B(NF-κB),transient receptor potential vanillin subfamily 1(TRPV1),5-hydroxytryptamine(5-HT),mitogen-activated protein kinase(M APK),and so on.Traditional Chinese medicine can repair intestinal inflammation,reduce visceral sensitivity,enhance intestinal mucosal barrier,and regulate intestinal motility by regulating this series of signaling pathways,thereby playing an important role in the treatment of IBS with multi-level,multi-link and multi-target characteristics.Based on the cell signaling pathways,this paper reviewed the research progress on the mechanism of traditional Chinese medicine in the treatment of IBS,hoping to provide theoretical support and diagnosis and treatment ideas for the clinical treatment of IBS with traditional Chinese medicine.
作者
李雨芹
赵美丹
张迪
王慎军
刘丹
LI Yuqin;ZHAO Meidan;ZHANG Di;WANG Shenjun;LIU Dan(Graduate School,Tianjin University of Traditional Chinese Medicine(TCM),Tianjin 301617,China;School of Acupuncture-Moxibustion and Tuina,Tianjin University of TCM,Tianjin 301617,China;School of Pharmaceutical Engineering of TCM,Tianjin University of TCM,Tianjin 301617,China;Tianjin Wuqing District TCM Hospital,Tianjin 301799,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第9期243-251,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
天津市卫生健康委员会中医中西医结合科研课题(2021160)
天津市自然科学基金面上项目(20JCYBJC00200)。
关键词
中医药
肠易激综合征
信号通路
研究进展
traditional Chinese medicine
irritable bowel syndrome
signaling pathways
research progress
作者简介
第一作者:李雨芹,在读硕士,从事中医药治疗消化疾病的机制研究,E-mail:1963568813@qq.com;通信作者:王慎军,副研究员,硕士生导师,从事针刺镇痛与针灸推拿抗抑郁的机制研究,E-mail:shenjunwang@163.com。
