摘要
目的探讨血清C反应蛋白(C–reactive protein,CRP)、降钙素原(procalcitonin,PCT)水平与肾结石患者经皮肾镜取石术(percutaneous nephrolithotomy,PCNL)治疗后尿路感染的关系。方法选取2020年1月至2021年12月于萍乡市人民医院治疗的肾结石患者124例,依据术后是否发生尿路感染分为无尿路感染组(n=96)与尿路感染组(n=28)。术后3d采集两组静脉血5ml,分别采用散射免疫比浊法、电化学发光法测定血清CRP、PCT水平。比较两组血清CRP、PCT水平,分析血清CRP、PCT水平与肾结石患者PCNL治疗尿路感染的相关性,以尿细菌培养诊断结果作为金标准,计算CRP、PCT单项及联合诊断尿路感染的敏感度及特异性。结果尿路感染组血清CRP、PCT水平高于无尿路感染组,差异有统计学意义(P<0.05);将血清CRP、PCT水平作为自变量,将肾结石患者PCNL治疗是否发生尿路感染作为因变量,线性回归结果显示,血清CRP、PCT水平与肾结石患者PCNL治疗尿路感染具有相关性(P<0.05),CRP+PCT联合诊断尿路感染敏感度高于CRP与PCT,PCT与CRP+PCT联合诊断尿路感染特异性高于CRP,差异均有统计学意义(P<0.05)。结论肾结石PCNL术后发生尿路感染患者的血清CRP、PCT水平较高,血清CRP、PCT水平与PCNL术后尿路感染间具有一定的关系,CRP、PCT联合诊断可提高尿路感染准确率,以为临床诊治提供指导,改善患者预后。
Objective To investigate the relationship between serum C–reactive protein(CRP)and procalcitonin(PCT)levels and urinary tract infection after percutaneous nephrolithotomy(PCNL)in patients with kidney stones.Methods A total of 124 patients with nephrolithiasis who were treated in Pingxiang City People's Hospital from January 2020 to December 2021 were selected and divided into no urinary tract infection group(n=96)and urinary tract infection(n=28)according to whether postoperative urinary tract infection occurred or not.Three days after the operation,5ml of venous blood was collected from the two groups,and the levels of serum CRP and PCT were measured by scattering immunoturbidimetry and electrochemiluminescence.The serum CRP and PCT levels of the two groups were compared,and the correlation between the serum CRP and PCT levels and PCNL treatment of urinary tract infection in patients with kidney stones was analyzed.The results of urine bacterial culture were used as the gold standard for the diagnosis,and the sensitivity and specificity of CRP and PCT alone and in combination for the diagnosis of urinary tract infection were calculated.Results The levels of serum CRP and PCT in the urinary tract infection group were higher than those in the no urinary tract infection group,and the differences were statistically significant(P<0.05).Linear regression results showed that serum CRP and PCT levels were closely related to PCNL treatment of urinary tract infection in patients with kidney stones(P<0.05).The sensitivity of diagnosing urinary tract infection was higher than that of CRP and PCT,and the specificity of PCT and CRP+PCT in diagnosing urinary tract infection was higher than that of CRP,and the differences were statistically significant(P<0.05).Conclusion The serum levels of CRP and PCT are higher in patients with urinary tract infection after PCNL after nephrolithiasis.There is a certain relationship between serum CRP and PCT levels and urinary tract infection after PCNL.The combined diagnosis of CRP and PCT can improve the accuracy of urinary tract infection,to provide guidance for clinical diagnosis and treatment and improve patient prognosis.
作者
卓林
ZHUO Lin(Department of Urology,Pingxiang City People's Hospital,Jiangxi,Pingxiang 337000,China)
出处
《中国现代医生》
2022年第29期38-41,共4页
China Modern Doctor
关键词
肾结石
经皮肾镜取石术
尿路感染
C反应蛋白
降钙素原
相关性
Kidney stones
Percutaneous nephrolithotomy
Urinary tract infection
C-reactive protein
Procalcitonin
Correlation
作者简介
通讯作者:卓林,电子信箱:liuxmfs@126.com。
