摘要
目的探讨血浆降钙素原(PCT)对不同病原菌感染老年脓毒血症患者的诊断价值。方法本研究纳入2017年1月-2020年12月我院内科收治的62例脓毒血症老年患者开展研究。所有患者均抽取静脉血12mL,其中4mL分别置于真空采血管内送往检验科进行C反应蛋白(CRP)及PCT水平测定,另外8mL置于血培养瓶内进行血培养。依据血培养结果,将结果显示为阴性的27例患者纳为甲组,结果显示阳性的35例患者纳入乙组,其中乙组患者又可根据病原菌不同分为真菌感染组(8例)、革兰氏阳性(G+)球菌感染组(11例)及革兰氏阴性(G-)杆菌感染组(16例);另抽取32例健康对照者纳入丙组;比较各组间CRP及PCT水平,分析PCT的敏感度、特异性及准确率。结果甲组及乙组CRP、PCT水平均高于丙组,乙组患者PCT水平显著高于甲组,差异有统计学意义(P<0.05);甲组与乙组CRP比较,差异无统计学意义(P>0.05);真菌感染组、G+球菌感染组及G-杆菌感染组CRP水平比较,差异无统计学意义(P>0.05);G-杆菌感染组患者PCT水平高于真菌感染组及G+球菌感染组,差异有统计学意义(P<0.05);PCT检测敏感度、特异性及准确率均高于CRP检测,差异有统计学意义(P<0.05)。结论PCT在老年脓毒血症患者不同病原菌感染鉴别诊断中合理应用具有重要意义,其具有较高的敏感度及特异性,有助于临床诊断准确率提高,从而为后续治疗开展提供参考依据。
Objective To discuss the diagnostic value of plasma procalcitonin(PCT)in elderly septicopyemia patients with different pathogenic bacteria infections.Methods 62 elderly septicopyemia patients treated from January 2017 to December 2020 in our hospital were investigated.12mL venous blood was drawn,which 4 mL blood was placed into vacuum tube for measurement of C-reactive protein(CRP)and PCT levels and 8mL blood was placed into culture flask.According to blood culture results,27 negative cases were set as group A and 35 positive cases as group B.According to different pathogenic bacteria,group B were further classified as fungal infection group(8 cases),gram-positive(G+)bacterial infection group(11 cases)and gram-negative(G-)bacterial infection group(16 cases);32healthy checkups were set as group C.CRP and PCT levels were compared;diagnosis sensitivity,specificity and accuracy based on PCT were analyzed.Results CRP and PCT levels in group A and group B were higher than group C;PCT levels in group B were higher than group A(P<0.05);CRP levels between group A and group B were not significantly different(P>0.05);CRP levels among fungal infection group,G+bacterial infection group and G-bacterial infection group were not significantly different(P>0.05);PCT levels in G-bacterial infection group were higher than fungal infection group and G+bacterial infection group(P<0.05);diagnosis sensitivity,specificity and accuracy based on PCT were higher than those based on CRP(P<0.05).Conclusion PCT is important to differential diagnosis of pathogenic bacteria infections,increasing the diagnosis sensitivity,specificity and accuracy,and providing basis on the subsequent treatment.
作者
陈宛文
朱晓佳
肖婉媚
梁俊彬
叶国辉
冯泉
CHEN Wan-wen;ZHU Xiao-jia;XIAO Wan-mei;LIANG Jun-bin;YE Guo-hui;FENG Quan(General Medical Department,Songshanhu Central Hospital of Dongguan,Dongguan,Guangdong 523326)
出处
《智慧健康》
2021年第34期19-21,共3页
Smart Healthcare
关键词
降钙素原
不同病原菌感染
老年患者
脓毒血症
C反应蛋白
敏感度
Procalcitonin
Different pathogenic bacteria infections
Elderly patients
Septicopyemia
C-reactive protein
Sensitivity
