摘要
【目的】分析接种新型冠状病毒疫苗(简称"新冠疫苗")后血清IgM和IgG抗体水平,为疫苗接种后抗体表达的研究提供参考信息。【方法】收集2021年7—8月在云南省昆明市第三人民医院检测新冠IgM和IgG抗体的健康体检者980例为研究对象,分析其抗体水平情况。【结果】接种疫苗后IgG抗体阳性469例,阳性率47.86%。其中,男性75例,阳性率39.06%,IgG水平0.618(0.180,2.526)AU·mL^(-1)[M(Q1,Q3)];女性394例,阳性率50.00%,IgG水平0.999(0.305,3.334)AU·mL^(-1)。IgM抗体阳性53例,阳性率5.41%。其中,男性14例,阳性率7.29%,IgM水平0.057(0.026,0.195)AU·mL^(-1);女性39例,阳性率4.95%,IgM水平0.047(0.027,0.110)AU·mL^(-1)。年龄≤30岁组IgG抗体阳性男性和女性均最高,分别为25例和133例,阳性率分别为51.02%和55.88%。IgG抗体阳性率和IgG水平在性别中差异显著(χ^(2)=7.401,D=0.135 1,P<0.05),IgM阳性率差异无统计学意义(χ^(2)=1.656,P>0.05)。各年龄组中IgG抗体阳性以≤30岁组和51~70岁组较高,分别为158例和122例,阳性率分别为55.05%和52.36%,抗体水平分别为1.209(0.426,4.386)AU·mL^(-1)和1.074(0.191,7.670)AU·mL^(-1)。各年龄组IgG和IgM抗体阳性率和IgG抗体水平比较差异均有统计学意义(χ^(2)=29.11、52.14,P<0.05),IgG和IgM抗体水平在各年龄组间经多组Kruskal-Wallis检验和Spearman相关性分析,显示两者间有较高的相关性,差异有统计学意义(r=0.836 4,H=64.82、20.09,P<0.05)。【结论】接种新冠疫苗6个月后IgG抗体阳性率仍较高,IgM抗体阳性率较低。IgM和IgG阳性率和表达水平在青年和中老年人群中较高,在性别和年龄上其表达水平存在差异且具相关性。
[Objective]To determine the serum IgM and IgG antibody levels post-COVID-19 vaccination,and provide scientific evidence for COVID-19 antibody response after vaccination.[Methods]A total of 980 healthy persons were included in Kunming Third People’s Hospital from July through August,2021,which had been vaccinated with COVID-19 vaccines and then tested for anti-SARS-CoV-2 IgM and IgG antibodies.[Results]After the COVID-19 vaccination,469 persons(positive rate,47.86%)were positive for anti-IgG antibody. Of them,75 were males with(positive rate,39.06%),and the average IgG level was 0.618(0.180,2.526)AU·mL^(-1)[M(Q1,Q3)];394 were females(50.00%),and the IgG level was 0.999(0.305,3.334)AU·mL^(-1). In addition,53 persons(5.41%)were anti-IgM antibody positive. Of them,14 were males(positive rate,7.29%),and the average IgM level was 0.057(0.026,0.195)AU·mL^(-1);39 were females(4.95%),and the IgM level was 0.047(0.027,0.110)AU·mL^(-1). The positive rate of anti-IgG antibody was highest in those aged ≤30 years,which was 51.02% in male(n=25)and 55.88% in female(n=133). The anti-IgG response differed significantly by gender(χ^(2)=7.401,D=0.135 1,P<0.05),whereas the anti-IgM response was not significantly different(χ^(2)=1.656,P>0.05). Among the age groups,anti-IgG antibody level was higher in those aged ≤30 and 51-70 years,with 158(55.05%)and 122(52.36%)persons,respectively;the average antibody level was 1.209(0.426,4.386)AU·mL^(-1)and 1.074(0.191,7.670)AU·mL^(-1),respectively. The differences in the positive rates of IgG and IgM antibodies and the levels of IgG antibodies among different age groups were statistically significant(P<0.05). Using Kruskal-Wallis test and Spearman correlation analysis,it showed a high correlation between the IgG and IgM antibodies(r=0.836 4,H=64.82,20.09,P<0.05).[Conclusion]The AntiSARS-CoV-2 IgG antibody remains high six months post-COVID-19 vaccination,while anti-IgM antibody is low. The IgM and IgG response are higher in the young and elderly. The response differs by gender and age,demonstrating a correlation.
作者
王霖
杜映荣
马志强
李杰
张淑琼
汤晓青
瞿春燕
段亚茹
李才信
WANG Lin;DU Yingrong;MA Zhiqiang;LI Jie;ZHANG Shuqiong;TANG Xiaoqing;QU Chunyan;DUAN Yaru;LI Caixin(The Third People’s Hospital of Kunming,Kunming,Yunnan 650301,China)
出处
《上海预防医学》
CAS
2022年第2期126-129,共4页
Shanghai Journal of Preventive Medicine
基金
云南省昆明市科学技术局计划项目(2020-1-N-050)
昆明市卫生科技人才培养“千”工程后备人选(2019-sw[后备]-25、2020-sw[后备]-72)。
作者简介
王霖,男,本科,主任检验师,研究方向:生化免疫及分子生物学,E-mail:626182669@qq.com。;并列第一作者:杜映荣,男,硕士,主任医师,研究方向:心血管内科学,E-mail:dyr_km@163.com。;通信作者:马志强,E-mail:18468279606@163.com。
