摘要
目的通过分析22例接种新型冠状病毒灭活疫苗(Vero细胞)后感染新型冠状病毒肺炎(COVID-19)患者的临床特征及抗体情况,方便临床预判和治疗。方法选取2020年12月—2021年3月在我院收治的22例接种灭活疫苗后的COVID-19患者为研究对象,通过分析其人口学特征、临床症状、血检结果、核酸及抗体、胸部影像学及治疗方法等,以了解接种灭活疫苗后COVID-19患者的临床特征及抗体变化情况。结果 22例COVID-19患者中位年龄34.5岁,临床症状主要有咳嗽(8例)、咳痰(3例)、纳差(3例)、发热(1例)、胸闷(1例)、咽喉不适(1例)、鼻塞流涕(1例)等;胸部影像学有单侧肺炎(2例)及双侧肺炎(7例),表现为磨玻璃影(5例)或磨玻璃合并斑片影(4例)。入院时1例患者查新冠病毒抗体IgM(+)IgG(-),3例IgM(-)IgG(-),4例IgM(-)IgG(+),14例IgM(+)IgG(+)。结论本次我院诊治的接种灭活新冠疫苗(Vero细胞)后COVID-19患者,以青中年男性居多,临床分型以普通型患者为主,临床症状主要有咳嗽、咳痰、发热、咽喉不适等,胸部影像学可出现单侧或双侧磨玻璃影或斑片影渗出病灶,经氧疗、中药等常规治疗后所有患者均预后良好。接种灭活新冠疫苗(Vero细胞)后再感染新冠病毒患者,可在短期内迅速产生大量IgG抗体。
Objective To analyze the clinical characteristics and antibody of 22 COVID-19 patients with the adsorbed SARS-CoV-2 vaccine innoculation, in order to benefit clinical prediction and treatment.Methods Totally 22 patients with COVID-19 after inactivated vaccination who were admitted to our hospital from December 2020 to March 2021 were selected as the research subjects. Demographic characteristic, clinical symptoms, blood tests, nucleic acids and antibody tests, chest CT and treatment methods were analyzed to figure out the clinical characteristics and antibody changes.Results The median age of 22 patients was 34.5 years old. The clinical symptoms were mainly cough(8 cases), expectoration(3 cases), poor appetite(3 cases), fever(1 case), chest tightness(1 case), throat discomfort(1 case) and nasal congestion and runny nose(1 case). The chest CT mainly showed unilateral pneumonia(2 cases) and bilateral pneumonia(7 cases), presenting as ground glass shadow(5 cases) or ground glass with patch shadow(4 cases). One patient’s antibody turned out to be IgM(+)IgG(-), three cases with IgM(-)IgG(-), four with IgM(-)IgG(+) and fourteen with IgM(+)IgG(+) on admission.Conclusion The majority of COVID-19 patients treated by our hospital after inoculation of inactivated SARS-CoV-2 vaccine(Vero cells) are young and middle-aged men, and the clinical classification is mainly common type patients. The clinical symptoms are mainly cough, sputum, fever,throat discomfort, etc., and the chest imaging can show unilateral or bilateral ground glass shadow or patch shadow exudation lesions. The prognosis was good with all patients cured by routine treatment such as oxygen therapy and traditional Chinese medicine. After inoculating inactivated Vero cells, the patients infected with COVID-19 can rapidly produce a large number of IgG antibodies in a short time.
作者
陈沐
韩俊彦
张德荣
李世闻
莫晓能
CHEN Mu;HAN Jun-yan;ZHANG De-rong;LI Shi-wen;MO Xiao-neng(Department of Respiratory Medicine,Guangzhou Eighth People's Hosipital,Guangzhou Medical University,Guangzhou)
出处
《中国热带医学》
CAS
2021年第10期985-989,共5页
China Tropical Medicine
作者简介
陈沐(1988-),男,博士,主治医师,研究方向:呼吸系统疾病。
