摘要
动脉粥样硬化(atherosclerosis,AS)是一种累及人体动脉的慢性炎症性疾病。细胞焦亡作为一种炎症性质的细胞程序性死亡方式,被证实与AS进展密切相关,其特点是细胞膜完整性被破坏,炎症因子及细胞内容物经膜孔释放引发局部强烈而持续的炎症反应。AS病变组织中的细胞焦亡因血液循环积聚的脂质而过度激活,继而释放大量炎症因子损伤血管内皮,促进AS病变的形成与发展,这与中医"痰瘀毒"致病机制相似。活血解毒类中药正是以"痰瘀毒"为病机治疗AS的药物,具有抗炎降脂、改善循环等作用。因此,活血解毒类中药可以将细胞焦亡作为靶点发挥抗AS的功效。
Atherosclerosis(AS)is a chronic inflammatory disease involving human arteries and is responsible for many clinical cardiovascular diseases.In recent years,various cell death modalities have become popular for research on the pathogenesis of AS.Pyroptosis,as a programmed cell death of inflammatory nature,has been shown to be closely related to the progression of AS,which is characterized by the complete destruction of cell membranes and the release of inflammatory factors and cell contents through membrane pores,to trigger a strong and sustained local inflammatory response.Pyroptosis in AS lesions is caused by the over-activation of lipid accumulation in blood circulation,followed by the release of a large amount of inflammatory factors and the damage of vascular endothelium under the action of inflammatory factors,finally promote the formation and development of AS lesions.This is very similar to the pathogenic theory of "phlegm stasis and toxicity" in traditional Chinese medicine(TCM).Therefore,blood activating and detoxifying herbs,which have the efficacy of anti-inflammatory,lipid-lowering,blood circulation promotion,and guided by TCM theory of "phlegm stasis and toxicity" as the onset and process of AS,may play a powerful role in treating AS by regulating pyroptosis.
作者
顾问
高京
陈思玉
崔鑫鑫
王贺
司春婴
关怀敏
GU Wen;GAO Jing;CHEN Siyu;CUI Xinxin;WANG He;SI Chunying;GUAN Huaimin(The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000 Henan,China;Medical College of Rehabilitation,Henan University of Chinese Medicine,Zhengzhou 450000 Henan,China;Department of Cardiology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000 Henan,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2021年第12期1877-1882,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金面上项目(81473507)
河南省科技厅科技攻关项目(212102311083)
河南省大学生创新创业训练计划项目(S202010471044)
河南中医药大学科研苗圃工程项目(MP2020-16)
河南中医药大学大学生创新学习项目(CXXM2020044)。
关键词
动脉粥样硬化
细胞焦亡
炎症小体
痰瘀毒
活血解毒类中药
Atherosclerosis
pyroptosis
inflammasome
phlegm stasis and toxicity
blood activating and detoxifying herbs
作者简介
顾问,男,硕士研究生,研究方向:心血管疾病基础与临床研究。Email:406118795@qq.com;通信作者:司春婴,男,硕士,讲师,主治医师,研究方向:中西医结合防治冠心病等心血管疾病的基础与临床研究。Email:chunyingsi1987@163.com。
