摘要
目的基于中国专利数据库对中药复方治疗慢性阻塞性肺疾病(简称慢阻肺)用药规律进行分析。方法检索中国专利数据库建库至2021年2月1日公布的治疗慢阻肺的中药复方,对复方药物的频次、性味、归经以及功效分类进行统计分析;采用Apriori算法及熵层次聚类分析的方法,挖掘核心药物、药组及新处方。结果共纳入中药复方73首,涉及中药307味,总用药频次934次。使用频次较高的中药有黄芪、甘草、白术、陈皮、苦杏仁等;药性以温、寒为主;药味多甘、苦,主归肺经、脾经;药物功效以化痰止咳平喘药、补气药、清热药为主;关联分析共获得10组药对组合,其中二项关联药对组合4组,三项关联药对组合6组;通过熵层次聚类分析发现新处方8首。结论中药复方治疗慢阻肺急性加重期以祛邪为主,稳定期重在扶正。以止咳化痰、益气扶正、清热肃肺、宣肺解表等为主要治法,多选择补气药,适当配伍补血、滋阴、补阳、祛痰、利水、化瘀等药物治疗,可为后续临床实践及新药研发提供参考。
Objective To analyze the medication rule of Chinese medicine compound prescriptions for the treatment of chronic obstructive pulmonary disease(COPD)based on the Chinese patent database.Methods We searched the Chinese patent database from the establishment to February 1st 2021 to find the Chinese medicine compound for the treatment of COPD.The frequency,nature and flavour,meridian and efficacy classification of the compound medicines were statistically analysed.Core drugs,drug groups and new prescriptions were mined by using Apriori algorithm and entropy hierarchical clustering analysis method.Results A total of 73 traditional Chinese medicine compound prescriptions were included,involving 307 Chinese medicines,and the total frequency of medication was 934 times.The most frequently used Chinese medicines were Radix astragali,Radix glycyrrhizae,Rhizoma atractylodis macrocephalae,Pericarpium citri reticulatae,Semen armeniacae amarum,etc.The medicinal properties are mainly warm and cold,and the medicinal flavors are sweet and bitter.The channel tropism mainly included the lung meridian and spleen meridian.The herbs had the effects of reducing phlegm,relieving cough and relieving asthma,invigorating qi and clearing heat.10 groups of drug pair combinations were obtained by association analysis,including 4 groups of combination of 2 herbs and 6 groups of combination of 3 herbs.8 new prescriptions were found through entropy hierarchical clustering analysis.Conclusion In the treatment of acute exacerbation of COPD,the traditional Chinese medicine compound mainly focuses on eliminating pathogens.But in the stable stage it focuses on strengthening the body resistance.The main treatment methods are relieving cough and reducing phlegm,replenishing qi and righting,clearing heat and relieving the lung,and dispelling the lungs.Qi tonics were often used,and appropriate combined with blood tonic,nourishing yin drug,tonifying yang drug,expectorant drug,diuretic drug,and stasis drug.The aim of this study was to provide reference for follow-up clinical practice and new medicine research and development.
作者
王军
张海龙
春柳
李建生
WANG Jun;ZHANG Hailong;CHUN Liu;LI Jiansheng(Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R.China,Henan Key Laboratory of Chinese Medicine for Respiratory Disease,Henan University of Chinese Medicine,Zhengzhou 450046 Henan,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003 Henan,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2021年第10期1556-1561,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金委员会重点项目(81830116)
河南省中医药科学研究专项课题(2019JDZX2004)
河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020007)。
关键词
慢性阻塞性肺疾病
中药复方
专利
数据挖掘
用药规律
驱邪
扶正
Chronic obstructive pulmonary disease
Chinese medicine compound prescription
patents
data mining
medication rule
eliminating pathogens
strengthening the body resistance
作者简介
王军,男,硕士研究生,研究方向:中医内科学呼吸方向。Email:wangj1758@163.com;通信作者:张海龙,男,博士,副教授,硕士研究生导师,研究方向:呼吸系统疾病诊疗及疗效评价研究。Email:zhanghailong6@126.com。
