摘要
目的探讨近代中医大家蒲辅周先生的临床治疗湿证的用药经验与组方规律,为传承其临床经验提供参考。方法收集整理蒲辅周先生医案处方共100首方剂,采用改进的互信息法、关联规则、复杂系统熵聚类、无监督的熵层次聚类,进行单药、对药、角药的统计、关联规则分析与新方发现。结果蒲辅周先生治疗湿证使用单药频次最高的为茯苓51次(占51.00%)、甘草42次(占42.00%)、通草42次(占42.00%),高频对药为通草-茵陈27次(占27.00%),通草-薏苡仁27次(占27.00%),半夏-茯苓26次(占26.00%),常用角药为滑石-通草-杏仁20次(占20.00%),通草-茯苓-薏苡仁18次(占18.00%),通草-薏苡仁-茵陈18次(占18.00%)。核心处方药物为茯苓、甘草、通草、薏苡仁、半夏。结论蒲辅周先生治疗湿证的用方以清·吴鞠通《温病条辨》的三仁汤、杏仁滑石汤等方剂为主,药物以茯苓、薏苡仁、通草等为主,用于临床时还应随证加减。
Objective To explore the medical experience and prescription patterns of modern Chinese medicine master Pu Fuzhou in the clinical treatment of dampness syndrome,so as to provide references for inheriting his clinical experience.Methods A total of 100 prescriptions from medical records of Mr.Pu Fu-chou were collected and collated,and the improved mutual information method,association rules,entropy clustering of complex systems,and unsupervised entropy hierarchical clustering were used for statistical,association rule analysis and new prescription discovery of single medicinal,pairs of medicinal,and corner medicinal.Results Mr.Pu Fuzhou used the single drug most frequently in treating dampness syndrome:51 times of Poria(51.00%),42 times of Radix Glycyrrhizae(42.00%),and 42 times of Medulla Tetrapanacis(42.00%).The high-frequency antidote was 27 times of Tetrapanacis-Herba Artemisiae Scopariae(accounting for 27.00%),27 times of Tetrapanacis-Semen Coicis(accounting for 27.00%),26 times of Rhizoma PinelliaePoria(accounting for 26.00%).The commonly used corner medicinal was 20 times of Talcum-Medulla TetrapanacisSemen Armeniacae Amarum(accounting for 20.00%),18 times of Medulla Tetrapanacis-Poria-Semen Coicis(accounting for 18.00%),18 times of Medulla Tetrapanacis-Semen Coicis-Herba Artemisiae Scopariae(accounting for 18.00%).The core prescription herbs were Poria,Radix Glycyrrhizae,Medulla Tetrapanacis,Semen Coicis and Rhizoma Pinelliae.Conclusion The prescriptions used by Mr.Pu Fuzhou for the treatment of dampness are mainly Sanren Decoction and Xingren Huashi Decoction in Qing·Wu Jutong’s Treatise on Differentiation And Treatment of Epidemic Febrile Disease,and the main medicines are Poria,Semen Coicis,Medulla Tetrapanacis,etc.,which are also used in clinical practice.
作者
张辉
何庆勇
惠小珊
但文超
孟培培
Zhang Hui;He Qingyong;Hui Xiaoshan;Dan Wenchao;Meng Peipei(Guang’anmen Hospital,China Academy of Chinese Medical Science,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第9期3195-3201,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
北京市科学技术委员会北京市科技新星计划(Z181100006218035):瓜蒌丹参颗粒对冠心病micro RNA-155及其靶基因调控网络的研究,负责人:何庆勇
关键词
组方规律
中医传承辅助系统
核心药物
湿证
Prescription law
Traditional Chinese medicine inheritance support system
Core medicinals
Dampness
作者简介
通讯作者:何庆勇,教授,主任医师,博士生导师,主要研究方向:中医药防治心血管疾病。
