摘要
目的探讨加用中药益肺活血方治疗慢性阻塞性肺疾病(简称慢阻肺)的临床疗效及对患者肺功能、炎性反应、氧化应激反应、生活质量的影响。方法选取潍坊市中医院2019年1月至2020年12月收治的慢阻肺患者93例作为研究对象,采用随机数字表法将患者随机分为观察组(n=47)和对照组(n=46)。对照组按照常规措施进行治疗,观察组在对照组基础上加用中药益肺活血方治疗。连续治疗1个月后比较两组患者临床有效率、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、用力肺活量(forced vital capacity,FVC)、1秒率(FEV1/FVC)、6 min步行距离(6 minute walk test,6MWT)、白细胞介素-8(IL-8)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、谷胱甘肽(glutathione,GSH)、过氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)及圣乔治呼吸问卷(St.George respiratory questionnaire,SGRQ)评分。结果治疗后观察组有效率为91.49%,高于对照组的71.74%,差异有统计学意义(P<0.05)。治疗后两组患者FEV1、FVC、FEV1/FVC、6MWT、SOD、GSH均明显增加,且治疗后观察组各指标均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者TNF-α、IL-6、IL-8、MDA含量均明显降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者SGRQ量表的疾病影响、活动能力、症状、总分均明显降低,且观察组均明显低于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为10.87%,观察组为10.64%,两组差异无统计学意义(P>0.05)。结论在常规治疗慢阻肺的基础上加用益肺活血方治疗可提高临床疗效,更大程度的改善患者生活质量,降低炎性反应和氧化应激反应,促进肺功能的恢复,且不会增加不良反应发生率。
Objective To explore the clinical efficacy of Yifei Huoxue Decoction in the treatment of chronic obstructive pulmonary disease(COPD)and its influence on pulmonary function,inflammatory reaction,oxidative stress reaction and quality of life.Methods A total of 93 patients with COPD in Weifang Traditional Chinese Medicine Hospital from January 2019 to December 2020 were selected as the research objects,and randomly divided into observation group(n=47)and control group(n=46)by random number table method.The control group was treated with routine measures,and the observation group was treated with Yifei Huoxue Decoction on the basis of the control group.The clinical effective rate,forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC,6 minute walking test(6 MWT),interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),glutathione(GSH),superoxide dismutase(SOD),malondialdehyde(MDA)and St.George respiratory questionnaire(SGRQ)were compared between the two groups after 1 month of continuous treatment.Results After treatment,the effective rate of the observation group was 91.49%,which was higher than 71.74%of the control group(P<0.05).After treatment,FEV1,FVC,FEV1/FVC,6 MWT,SOD and GSH of the two groups were significantly increased,and they were higher in the observation group than those in the control group(P<0.05).After treatment,the levels of TNF-α,IL-6,IL-8 and MDA in the two groups were significantly decreased,and they were lower in the observation group than those in the control group(P<0.05).After treatment,the disease influence,activity ability,symptoms and total score of SGRQ scale in the two groups were significantly decreased,and they were lower in the observation group than those in the control group(P<0.05).The incidence of adverse reactions was 10.87%in the control group and 10.64%in the observation group,and there was no significant difference between the two groups(P>0.05).Conclusion On the basis of conventional treatment of COPD,Yifei Huoxue Decoction can improve the clinical efficacy,improve the quality of life of patients,reduce inflammatory reaction and oxidative stress reaction,promote the recovery of lung function,and will not increase the incidence of adverse reactions.
作者
王长英
WANG Chang-ying(Pharmacy Department,Weifang Traditional Chinese Medicine Hospital,Weifang,Shandong 261041,China)
出处
《慢性病学杂志》
2021年第9期1321-1324,1328,共5页
Chronic Pathematology Journal
关键词
慢性阻塞性肺疾病
肺功能
生活质量
氧化应激反应
Chronic obstructive pulmonary disease
Lung function
Quality of life
Oxidative stress response
作者简介
通信作者:王长英,大学本科,主管中药师,研究方向:中药临床,E-mail:wangchangying0412@163.com
