摘要
目的对比不同血清鸢尾素水平妊娠期亚临床甲状腺功能减退症(SCH)患者血脂和凝血功能。方法选取106例妊娠期SCH患者作为病例组,选取同期100名在妇产科接受产检的孕妇作为对照组。对两组研究对象的一般资料、血清鸢尾素水平、甲状腺功能指标、甲状腺相关抗体及血脂指标、凝血功能指标进行检测和对比。结果病例组患者的体质指数(BMI)水平及血清促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPO-Ab)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白原(FIB)及鸢尾素水平高于对照组,血清高密度脂蛋白胆固醇(HDL-C)水平及活化部分凝血活酶时间(APTT)水平均低于对照组,两组之间的差异有统计学意义(P<0.05);但两组研究对象血清游离甲状腺素(FT4)水平的差异无统计学意义(P>0.05)。以病例组患者的血清鸢尾素水平均值为划分界值,将病例组分为高鸢尾素组(55例)和低鸢尾素组(51例),高鸢尾素组患者的血清TSH、TC、TG、LDL-C及FIB水平均高于低鸢尾素组,APTT水平均低于低鸢尾素组,两组之间的差异均有统计学意义(P<0.05)。患者的血清鸢尾素水平与血清TSH、TG、TC、LDL-C、FIB水平呈正相关关系(P<0.05),与APTT水平呈负相关关系(P<0.05)。结论妊娠期SCH患者表现为脂代谢和凝血功能异常及血清鸢尾素水平升高,血清鸢尾素水平较高患者的脂代谢和凝血功能异常程度更加严重,患者的血清鸢尾素水平与其血脂指标和凝血指标具有相关性,可用于评价机体的代谢功能状态、辅助预测患者的妊娠结局。
Objective To compare the blood lipid and the coagulation function in the patients with subclinical hypothyroidism(SCH)during pregnancy with different serum Irisin levels.Methods 106cases of pregnant women with SCH during pregnancy were selected as the case group,and 100pregnant women examined in the department of obstetrics and gynecology during the same period were selected as the control group.The general information,the serum Irisin level,the thyroid function indexes,the thyroid related antibody,the blood lipid indexes and the coagulation function indexes between the subjects in the two groups were detected and compared.Results The levels of body mass index(BMI)and the thyroid stimulating hormone(TSH),the thyroid peroxidase antibody(TPO-Ab),the total cholesterol(TC),the triglyceride(TG),the low density lipoprotein cholesterol(LDL-C)and the fibrinogen(FIB)in serum of the patients in the case group were higher than those in the control group.The levels of serum high density lipoprotein cholesterol(HDL-C)in serum and the activated partial thromboplastin time(APTT)of the patients in the case group were lower than those in the control group,the differences between the two groups were statistically significant(P<0.05),but there was no significant difference in serum free thyroxine(FT4)between the two groups(P>0.05).The mean value of serum Irisin level was taken as cut-off value in case group,the patients were divided into the high Irisin group(55cases)and the low Irisin group(51cases).The serum TSH,TC,TG,LDL-C and FIB levels of the patients in the high Irisin group were higher than those in the low Irisin group,and the APTT level was lower than those the low Irisin group,the differences between the two groups were statistically significant(P<0.05).The serum Irisin level was positively correlated with serum TSH,TG,TC,LDL-C and FIB levels(P<0.05),and negatively correlated with APTT level(P<0.05).Conclusion The abnormal lipid metabolism and coagulation function as well as the increase of serum Irisin level were observed in the patients with SCH during pregnancy.The abnormal degree of lipid metabolism and coagulation function was more serious in patients with higher serum Irisin level.The serum Irisin level was correlated with blood lipid indexes and coagulation indexes,which could be used to evaluate the metabolic function of the body and predict the pregnancy outcome.
作者
邓文娟
王静
宁改君
张秋子
张志英
DENG Wen-juan;WANG Jing;NING Gai-jun(Department of Endocrinology,The First Affiliated Hospital of Hebei North University,Zhangjiakou075000,China)
出处
《中国实验诊断学》
2021年第9期1288-1292,共5页
Chinese Journal of Laboratory Diagnosis
基金
河北省卫生厅科研基金项目(20180850)。
