摘要
【目的】探讨术前血小板淋巴细胞比值(PLR)与甲状腺癌患者预后的相关性。【方法】本院收治的甲状腺癌患者258例,依据患者术前PLR分为A组(PLR≤150,168例)和B组(PLR>150,90例)。比较两组患者术前三碘甲腺原氨酸(T_(3))及血清总甲状腺素(T_(4))水平、术前抗甲状腺球蛋白抗体(Tg-Ab)及抗甲状腺过氧化物酶抗体(TPO-Ab)水平、是否合并桥本甲状腺炎、TNM分期以及肿瘤大小、病理分型及是否合并,淋巴结转移等资料。所有患者术后每3个月在本院门诊复诊1次,共4次。常规复查局部彩超,必要时行细针穿刺活检病理检查以判定肿瘤复发情况,对所得数据进行统计学分析。【结果】两组术前Tg-Ab及TPO-Ab水平、合并桥本甲状腺炎情况、TNM分期及淋巴结转移情况相比较差异均无显,著性(均P>0.05)。两组术前血清T_(3)及T_(4)水平、肿瘤大小及病理分型相比较差异具有显著性(均P<0.05)。肿瘤大小、病理分型、术前血清T_(3)及T_(4)水平是术前PLR的独立影响因素(均P<0.05)。两组患者术后6个月、9个月及12个月的肿瘤复发率组间相比较差异均无显著性(均P>0.05)。【结论】肿瘤大小、病理分型、术前血清T_(3)及T_(4)水平是术前PLR的影响因素,但术前PLR对甲状腺癌预后时预测作用尚需进一步研究。
【Objective】To explore the correlation between preoperative blood platelet-to-lymphocyte ratio(PLR)and clinical prognosis of thyroid cancer.【Methods】A total of 258 cases of thyroid cancer treated in our hospital from January 2018 to January 2021 were enrolled in the study.According to value of PLR,they were divided into group A(PLR≤150,168 cases)and group B(PLR>150,90 cases).The data of preoperative Triiodothyronine(T_(3)),serum total thyroxine(T_(4))levels,preoperative anti-thyroglobulin antibody(Tg-Ab),anti-thyroid peroxidase antibody(TPO-Ab),Hashimoto's thyroiditis,TNM staging,tumor size,pathological type and lymph node metastasis were collected.All patients were required to have a follow-up visit every 3 months after surgery,for 4 times in total.Ultrasonography was performed for every review,and fine-needle aspiration biopsy pathological examination would be performed,if necessary,to determine the tumor recurrence.Statistical analysis was performed on the obtained data.【Results】There were no significant differences in Tg-Ab,TPO-Ab,Hashimoto's thyroiditis,TNM staging,and lymph node metastasis between two groups(P>0.05).There were significant differences in serum T_(3) and T_(4) levels,tumor size,and pathological types between two groups before surgery(P<0.05).Tumor size,pathological type,and preoperative serum T_(3) and T_(4) levels were independent influencing factors of preoperative PLR(P<0.05).There,was no significant difference in the tumor recurrence rates between two groups at 6th,9th and 12th months after surgery(P>0.05).【Conclusion】Tumor size,pathological type,and preoperative serum T_(3) and,T_(4) levels are influencing factors of preoperative PLR,but the predictive effect of preoperative PLR on the prognosis of thyroid cancer needs further study.
作者
任博博
闵琦
REN Bo-bo;MIN Qi(Department of Gastrointestinal Surgery,Shangluo Central Hospital,Shangluo Shaanxi,726000)
出处
《医学临床研究》
CAS
2021年第8期1183-1186,共4页
Journal of Clinical Research
关键词
甲状腺肿瘤
比值比
淋巴细胞
血小板
Thyroid Neoplasms
Odds Ratio
Lymphocytes
Blood Platelets
作者简介
通讯作者:闵琦,E-mail:13488303660@139.com。
