摘要
目的研究曲美他嗪联合瑞舒伐他汀对稳定型心绞痛患者心功能、血脂指标及血液流变学指标的影响。方法按照随机数字表法将2016年2月至2018年2月湖南省人民医院(湖南师范大学附属第一医院)收治的102例稳定型心绞痛患者分成对照组(51例)和观察组(51例)。两组患者均予以常规治疗,对照组患者在常规治疗的基础上予以瑞舒伐他汀进行治疗,观察组患者则在对照组的基础上联合曲美他嗪进行治疗,均治疗1个月。将两组患者治疗后临床疗效,治疗前后心功能指标、血脂指标及血液流变学指标水平进行比较。结果治疗后,观察组患者临床总有效率为88.24%,高于对照组的70.59%;与治疗前比,治疗后两组患者射血分数(EF)、心脏指数(CI)、心输出量(CO)、每搏输出量(SV)、血清高密度脂蛋白胆固醇(HDL-C)水平均升高,且观察组高于对照组;与治疗前比,治疗后两组患者血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平及全血高切黏度、全血低切黏度、血浆黏度水平均下降,且观察组低于对照组(均P<0.05)。结论稳定型心绞痛患者使用曲美他嗪联合瑞舒伐他汀进行治疗,可提高其临床治疗效果,改善心功能,调节血脂与血液流变学指标水平,治疗效果较为显著。
Objective To study the effects of Trimetazidine combined with Rosuvastatin on cardiac function,blood lipid index and hemorheology index in patients with stable angina pectoris.Methods A total of 102 patients with table angina pectoris who were admitted to Hunan Provincial People's Hospital(The First Affiliated Hospital of Hunan Normal University)from February 2016 to February 2018 were divided into the control group(51 cases)and the observation group(51 cases)according to the random number table method.Patients in both groups received conventional treatment,patients in the control group were treated with Rosuvastatin on the basis of conventional treatment,while patients in the observation group were treated with Trimetazidine on the basis of the control group,both groups were treated for 1 month.The clinical efficacy after treatment,cardiac function index,blood lipid index and hemorheology index before and after treatment of patients were compared between the two groups.Results After treatment,the total clinical effective rate in the observation group was 88.24%,which was higher than that 70.59%in the control group;compared with before treatment,the levels of ejection fraction(EF),cardiac index(CI),cardiac output(CO),stroke volume(SV)and high density lipoprotein cholesterol(HDL-C)levels of patients in the two groups increased after treatment,and the observation group was higher than the control group;compared with before treatment,the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity of patients in the two groups decreased after treatment,and the observation group was lower than the control group(all P<0.05).Conclusion Trimetazidine combined with Rosuvastatin for the treatment of patients with stable angina pectoris can increase the clinical efficacy,improve cardiac function,regulate the levels of blood lipid and hemorheology index,and the treatment effect is more significant.
作者
梁峰翎
彭友
李华桦
周艳
LIANG Fengling;PENG You;LI Huahua;ZHOU Yan(Three Department of Geriatrics,Hunan Provincial People's Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha,Hunan 410061,China)
基金
湖南省卫生计生委科研计划课题项目(编号:C2016012)。
关键词
稳定型心绞痛
曲美他嗪
瑞舒伐他汀
心功能
血脂
血液流变学
Stable angina pectoris
Trimetazidine
Rosuvastatin
Cardiac function
Blood lipid
Hemorheology
作者简介
梁峰翎,硕士研究生,主治医师,研究方向:老年疾病的诊疗;通信作者:周艳,硕士研究生,副主任医师,研究方向:老年疾病的诊疗。E-mail:36029907@qq.com。
