摘要
早发性卵巢功能不全(premature ovarian insufficiency,POI)是一种严重影响育龄妇女生殖健康和生活质量的内分泌疾病,目前尚无有效的恢复卵巢功能的治疗手段。近年来很多研究表明,不同来源的间充质干细胞(mesenchymal stem cells,MSC)通过改善卵巢组织微环境、免疫调节、促进卵泡发育、抑制颗粒细胞凋亡等,恢复POI患者的卵巢功能及生育能力。本文综述了POI的治疗方法研究现状、不同来源的MSC及其外泌体治疗POI的可能性评估及机制的研究进展。
Premature ovarian insufficiency(POI)is an endocrine disease that seriously affects reproductive health and life quality of women of childbearing age.At present,there is no effective treatment to restore ovarian function.In recent years,many studies have shown that different sources of mesenchymal stem cells(MSC),cytokines and exosomes secreted by MSC can restore the ovarian function and fertility of POI patients by improving the microenvironment of ovarian tissue,immunomodulation,promoting follicular development,inhibiting granulosa cell apoptosis and so on.This article reviewed the current status of the treatment of POI,the possibility assessment and mechanism of different MSC and their exosomes.
作者
赵馨扬
谭季春
Zhao Xinyang;Tan Jichun(Center of Reproductive Medicine,Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University/Key Laboratory of Reproductive Disorders and Fertility Remolding,Liaoning Province,Shenyang 110022,China)
出处
《中华生殖与避孕杂志》
CSCD
北大核心
2021年第7期661-667,共7页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金面上项目(61873257)
辽宁省重点研发计划指导计划项目(2018225093)。
作者简介
通信作者:谭季春,Email:tjczjh@163.com,电话:+86-18940251868。
