摘要
目的探讨坤泰胶囊联合人工周期激素疗法对早发性卵巢功能不全(POI)患者卵巢储备功能及血清维生素E结合糖蛋白(Afamin)、单核细胞中E3泛素连接酶(Peli1)水平的影响,以期为临床治疗提供参考。方法选取2021年3月—2024年2月陕西中医药大学附属医院收治的POI患者106例为研究对象。采用随机数字表法将患者分为对照组与联合组,各53例。对照组患者采用人工周期激素疗法。联合组患者采用坤泰胶囊联合人工周期激素疗法。2组患者均治疗6个月经周期。比较2组患者治疗前后中医证候积分、卵巢总体积(TOV)、窦卵泡细胞数(AFC)及Afamin、Peli1水平;治疗结束后,比较2组患者治疗效果;比较2组患者治疗前后(月经周期第4天采血检测)卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))水平。结果治疗前,2组患者中医证候积分中主、次证积分比较,差异无统计学意义(P>0.05)。治疗后,2组患者中医证候积分中主、次证积分均低于治疗前,且联合组低于对照组,差异均有统计学意义(P<0.05)。联合组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,2组患者FSH、LH及E_(2)水平比较,差异无统计学意义(P>0.05)。治疗后,2组患者FSH、LH水平均低于治疗前,E_(2)水平高于治疗前,同时联合组患者FSH、LH水平均低于对照组,E_(2)水平高于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者TOV、AFC比较,差异无统计学意义(P>0.05);治疗后,2组患者TOV大于治疗前,AFC多于治疗前,同时联合组患者TOV大于对照组,AFC多于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者Afamin、Peli1水平比较,差异无统计学意义(P>0.05)。治疗后,2组患者Afamin、Peli1水平低于治疗前,且联合组低于对照组,差异均有统计学意义(P<0.05)。结论坤泰胶囊联合常规人工周期激素疗法治疗POI,可有效调节性激素紊乱状态,改善卵巢储备功能,并调节血清Afamin、Peli1水平,疗效显著,值得临床推广应用。
Objective To investigate the effects of Kuntai capsule combined with artificial cycle hormone therapy on ovarian reserve function and serum levels of Afamin(vitamin E-binding glycoprotein)and Peli1(E3 ubiquitin ligase in monocytes)in patients with premature ovarian insufficiency(POI),aiming to provide a reference for clinical treatment.Methods A total of 106 POI patients admitted to the Affiliated Hospital of Shaanxi University of Chinese Medicine from March 2021 to February 2024 were selected as research participants.Patients were allocated to a control group and a combination group using a random number table,with 53 patients in each group.The control group received artificial cycle hormone therapy.The combination group received Kuntai Capsule combined with artificial cycle hormone therapy.Both groups were treated for 6 menstrual cycles.Traditional Chinese Medicine(TCM)syndrome scores,total ovarian volume(TOV),antral follicle count(AFC),and serum Afamin and Peli1 levels were compared between the two groups before and after treatment.Therapeutic efficacy was compared between the two groups after treatment.Follicle-stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E_(2))levels were compared between the two groups before and after treatment(measured from blood samples collected on day 4 of the menstrual cycle).Results Before treatment,there were no statistically significant differences in primary and secondary symptom scores of TCM syndrome between the two groups(P>0.05).After treatment,primary and secondary symptom scores decreased in both groups compared to before treatment,and the combination group had lower scores than the control group,with statistically significant differences(P<0.05).The overall response rate was significantly higher in the combination group than in the control group(P<0.05).Before treatment,there were no statistically significant differences in FSH,LH,or E_(2)levels between the two groups(P>0.05).After treatment,FSH and LH levels decreased in both groups compared to before treatment,while E_(2)levels increased;moreover,the combination group had significantly lower FSH and LH levels and higher E_(2)levels than the control group(P<0.05).Before treatment,there were no statistically significant differences in TOV or AFC between the two groups(P>0.05);after treatment,TOV increased and AFC increased in both groups compared to before treatment;furthermore,the combination group had significantly greater TOV and more AFC than the control group(P<0.05).Before treatment,there were no statistically significant differences in serum Afamin or Peli1 levels between the two groups(P>0.05).After treatment,serum Afamin and Peli1 levels decreased in both groups compared to before treatment,and the combination group had significantly lower levels than the control group(P<0.05).Conclusion Kuntai capsule combined with conventional artificial cycle hormone therapy for POI effectively strengthens therapeutic efficacy,regulates sex hormone imbalances,promotes ovarian reserve function,and modulates serum Afamin and Peli1 levels,making it worthy of clinical promotion and application.
作者
杨丽丽
王灿灿
白俊
杨爽
齐巧霞
朱虹丽
李丹妮
王海静
Yang Lili;Wang Cancan;Bai Jun;Yang Shuang;Qi Qiaoxia;Zhu Hongli;Li Danni;Wang Haijing(Department of Gynecology,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712000,China)
出处
《保健医学研究与实践》
2025年第5期84-89,共6页
Health Medicine Research and Practice
基金
陕西省自然科学基础研究计划项目——一般项目(青年)(2023-JC-QN-0899)。
作者简介
第一作者:杨丽丽,E-mail:yllworld66@163.com;通信作者:王灿灿,E-mail:1101267693@qq.com。
