摘要
背景:已有许多研究表明了间充质干细胞在疾病治疗和再生医学领域具有广阔的应用前景,另外,除了间充质干细胞本身,来源于间充质干细胞的外泌体也成为研究者关注的热点,有望成为新的疾病诊疗方法。目的:综述间充质干细胞及其外泌体在肝再生领域中的应用、挑战及前景,深入了解其发挥作用的治疗机制。方法:以"mesenchymal stem cells,MSCs,exosomes,liver,regenerate""间充质干细胞,外泌体,肝,再生"为检索词,检索PubMed数据库、万方数据库、CNKI数据库中发表的相关文献,通过筛选整理,排除与研究内容无关的文献、重复性研究和过早发表的文献,最终保留85篇文献进行综述。结果与结论:通过对现有的研究总结了间充质干细胞及其外泌体能够发挥肝脏保护作用并延缓疾病进展,具体机制包括减少肝细胞凋亡、调节自噬、改善炎症反应、改善氧化应激、抑制纤维化、促进血管生成等,可作为肝损伤相关疾病治疗研究的新方向。
BACKGROUND:Many studies have shown that mesenchymal stem cells have broad application prospects in the field of regenerative medicine.In addition to mesenchymal stem cells themselves,exosomes derived from mesenchymal stem cells have also become the focus of researchers’attention,which brings new ideas for the treatment of diseases.OBJECTIVE:To review the application,challenge and prospect of mesenchymal stem cells and their exosomes in the field of liver regeneration,and to further understand their therapeutic mechanism.METHODS:With the search terms of"mesenchymal stem cells,MSCs,exosomes,liver,regenerate",relevant articles published in PubMed database,Wanfang database and CNKI database were searched.Through screening and sorting,the articles unrelated to the research content,repetitive studies and early published articles were excluded.Finally,85 articles were reserved for review.RESULTS AND CONCLUSION:Mesenchymal stem cells and their exosomes can play a protective role in the liver and delay the progress of the disease.The specific mechanisms include reducing hepatocyte apoptosis,regulating autophagy,improving inflammatory response,improving oxidative stress,inhibiting fibrosis,and promoting angiogenesis,which can be used as a new direction for the treatment of liver injury related diseases.
作者
白佳萌
刘光伟
谢露
毛垚耀
何惠昌
王春景
Bai Jiameng;Liu Guangwei;Xie Lu;Mao Yaoyao;He Huichang;Wang Chunjing(Department of Gastroenterology,First Clinical School of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China;Department of Gastroenterology,First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2022年第19期3071-3077,共7页
Chinese Journal of Tissue Engineering Research
基金
河南省中医药科学研究专项课题项目(2019ZYBJ04),项目负责人:刘光伟。
关键词
干细胞
间充质干细胞
外泌体
肝再生
机制
综述
stem cells
mesenchymal stem cells
exosomes
liver regeneration
mechanism
review
作者简介
第一作者:白佳萌,女,1994年生,河南省周口市人,汉族,在读硕士,主要从事消化系统疾病的防治研究。https://orcid.org/0000-0002-5939-2059;通讯作者:刘光伟,主任医师,副教授,河南中医药大学第一附属医院消化科,河南省郑州市450000。
