摘要
骨骼肌占人体体重的40%以上,是摄取葡萄糖的主要部位,对维持血糖平衡和稳定起着十分重要的作用。骨骼肌糖代谢受损与胰岛素抵抗关系密切。骨骼肌糖代谢水平也是影响有氧运动能力的重要因素。骨骼肌糖代谢水平除了受遗传、营养、运动等影响外,也受生物钟的调节。从骨骼肌生物钟概述、骨骼肌核心生物钟分子对骨骼肌结构与功能的影响、运动对骨骼肌核心生物钟基因节律表达的影响以及运动介导骨骼肌生物钟对糖代谢的可能调控作用几个方面,综述运动、骨骼肌生物钟与糖代谢调控最新研究进展,以期从骨骼肌生物钟的角度探讨运动对糖代谢的调节作用。
Skeletal muscle accounts for more than 40%of the body weight.It is the major part of glucose intake and plays a key role in maintaining blood glucose balance and stability.Impaired skeletal muscle glucose metabolism is closely related to insulin resistance.The level of skeletal muscle glucose metabolism is also an important factor affecting aerobic exercise capacity,and it is not only affected by genetics,nutrition,exercise,etc.,but also regulated by the molecular clock.This article focuses on the overview of the skeletal muscle molecular clock,the influence of core skeletal muscle clock molecules on the structure and function of skeletal muscle,the influence of exercise on the rhythm expression of core skeletal muscle clock genes,and the possible regulatory effects of exercisemediated skeletal muscle molecular clock on glucose metabolism.It is hoped that the regulatory effects of exercise on glucose metabolism can be explored from the perspective of skeletal muscle molecular clock.
作者
严露
朱镕鑫
张缨
YAN Lu;ZHU Rong-xin;ZHANG Ying(School of Kinesiology,Beijing Sport University,Beijing 100084,China;Shanghai Institute of Sport Science&Shanghai Anti-doping Agency,Shanghai 200030,China)
出处
《北京体育大学学报》
CSSCI
北大核心
2021年第7期114-122,共9页
Journal of Beijing Sport University
基金
国家自然科学基金资助项目“CHRONO-BMAL1通路调节骨骼肌糖代谢及其影响有氧运动能力的分子机制”(项目编号:32071168)
中央高校基本科研业务费专项基金“CHRONO-BMAL1通路对有氧运动中小鼠骨骼肌糖代谢的影响”(项目编号:20211004)。
关键词
运动
骨骼肌
生物钟
糖代谢
exercise
skeletal muscle
molecular clock
glucose metabolism
作者简介
严露,博士研究生,研究方向运动与骨骼肌代谢适应。;通信作者:张缨,教授,博士,博士研究生导师,研究方向运动与骨骼肌代谢适应。
