摘要
目的分析苏皖地区变应性鼻炎(allergic rhinitis,AR)患者变应原的分布特征。方法选取2018年11月~2020年1月在南京医科大学第一附属医院耳鼻咽喉科就诊的苏皖地区鼻炎患者,详细采集临床资料并进行血清特异性IgE(sIgE)检测,分析sIgE阳性率及其受性别、年龄和就诊季节的影响。组间阳性率的比较采用χ2检验,多组间阳性率的比较经Bonferroni校正,多组间阳性率的线性关联分析采用线性趋势卡方检验。结果在589例鼻炎患者中,423例(71.8%)患者确诊为AR。吸入性变应原主要为户尘螨、粉尘螨,食入性变应原主要为虾、鸡蛋白、牛奶。吸入性变应原阳性率(97.4%)显著高于食入性变应原阳性率(30.7%)。男性链格孢霉阳性率高于女性。在不同年龄组中,sIgE阳性率随年龄的增长而降低。在未成年组,狗毛、链格孢霉、鸡蛋白和牛奶阳性率均高于成年组。在成年组,白栎木、艾蒿、草混合物和虾阳性率高于未成年组。狗毛夏季检出率高于秋冬季,链格孢霉夏季检出率高于其他季节。结论苏皖地区常见的吸入性变应原为户尘螨、粉尘螨和链格孢霉,常见的食入性变应原为虾、鸡蛋白和牛奶,不同性别、年龄和季节可导致变应原阳性率的差异。
Objective To analyze the distribution characteristics of allergens in patients with allergic rhinitis(AR)in Jiangsu and Anhui areas.Methods Serum specific IgE(sIgE)was detected in rhinitis patients from Jiangsu and Anhui provinces in order to analyze the distribution of sIgE and the effects of gender,age,and season on the distributions of sIgE.The Chi-square test was used to analyze the positive rates of groups,and pairwise comparison of positive rates among multiple groups was adjusted by Bonferroni correction.The linear trend test was utilized to analyze the linear correlation of multiple groups.Results Among 589 rhinitis patients,423(71.8%)were diagnosed with AR.The main inhaled allergens were Dermatophagoides pteronyssinus and Dermatophagoides farinae,while food allergens were mainly shrimp,egg white and milk.Meanwhile,the positive rate of inhaled allergens(97.4%)was significantly higher than that of food allergens(30.7%).The positive rate of Alternaria in males was higher than that in females.The positive rate of sIgE was negatively correlated with age in different age groups.The positive rates of dog hair,Alternaria,egg white and milk in the juvenile group were higher than those in the adult group.The positive rates of white oak,Artemista,grass mixture and shrimp in the adult group was higher than those in the juvenile group.In addition,we found that the positive rate of dog hair in summer was higher than that in autumn and winter,and the positive rate of Alternaria was the highest in summer compared with the other three seasons.Conclusions In Jiangsu and Anhui provinces,the common inhaled allergens in AR patients were Dermatophagoides pteronyssinus,Dermatophagoides farina,and Alternaria.The food allergens were mainly shrimp,egg white and milk.Sex,age and season could influence the distribution characteristics of allergens.
作者
陈敏
陆美萍
程雷
CHEN Min;LU Meiping;CHENG Lei(Department of Otorhinolaryngology,The First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,Jiangsu,China)
出处
《中国中西医结合耳鼻咽喉科杂志》
2021年第3期188-194,199,共8页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
作者简介
通信作者:程雷,主任医师,Email:chenglei@jsph.org.cn。
