摘要
目的探讨鼻息肉的遗传方式以及遗传因素在鼻息肉发病中的影响。方法采用遗传流行病学病例对照研究方法,对120例鼻息肉先证者家系和160例对照家系的鼻息肉患病情况进行研究,就其分离比(Li-Mantel-Gart 法)、患病率、遗传度(Falconer 法)进行分析。结果鼻息肉的分离比为0.124,95%可信限为0.081～0.167。先证者Ⅰ、Ⅱ级亲属鼻息肉的患病率分别是8.571%和3.086%,两者比较差异有统计学意义(x^2=24.851,P<0.01),二者分别与对照组Ⅰ、Ⅱ级亲属相应患病率1.376%和1.141%比较,差异有统计学意义(x^2=33.547和14.274,P 值均<0.01)。鼻息肉先证者Ⅰ、Ⅱ级亲属遗传度分别为64.488%和61.947%。在先证者Ⅰ级亲属中,成年人和未成年人鼻息肉遗传度分别为60.735%和74.598%,差异有统计学意义(x^2=4.504,P<0.05);复发组和初发组遗传度分别是74.304%和62.839%,差异有统计学意义(x^2=4.105,P<0.05)。结论鼻息肉符合多基因遗传的特点;遗传因素在鼻息肉发病中起重要作用,其中末成年人患者和复发的鼻息肉患者受遗传因素的影响更大。
Objective To investigate the genetic mode of nasal polyp and the effect of genetic factor on occurrence of the disease. Methods A genetic epidemiological case-control study including 280 pedigrees （120 nasal polyp cases and 160 controls） was conducted. The segregation ratio and the heritability of nasal polyp were respectively estimated by the Li-Mantel-Gart method and the Falconer method. Results The segregation ratio was 0. 124 （ 95 % CI 0. 081 - 0. 167 ）, significantly lower than 0. 25, which showed that nasal polyp did not possess the characteristics of monogenetic model. The prevelence rate of first-degree and second-degree relatives in cases were 8. 571% and 3. 086% respectively, which were significantly different （ Х^2 =24. 851 ,P 〈0. 01 ） and were higher than that noticed 1. 376% and 1. 141% in controls （ Х^2 = 33. 547 and 14. 274, all P 〈 0. 01 ）. The heritability of the first-degree and second-degree relatives of nasal polyp was 64. 488% and 61. 947%, Among the first-degree relatives of nasal polyp probands, the heritability of the adult group and the children group were respectively 60. 735% and 74. 598% （the difference was significant,Х^2 = 4. 504, P 〈 0. 05 ）. The heritability of the first-occurred group was 62. 839% and the recurred group was 74. 304% （the difference was significant, Х^2 = 4. 105, P 〈 0. 05 ）. Conclusions This study indicated that the genetic model of nasal polyp belonged to polygenetics and the genetic factors played an important role in the occurrence of nasal polyp, especially for young or recurred patients.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2007年第8期608-611,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词
鼻息肉
流行病学研究
遗传学
Nasal polyps
Epidemiologic studies
Genetics
作者简介
通讯作者：瞿申红，Email：qshdoetor@163．com.
