摘要
目的探讨低pH缓冲生理海水鼻腔喷雾在气传花粉所致变应性鼻炎继发慢性鼻窦炎患儿中的应用效果。方法选取2021年4月至2023年4月该科收治的97例变应性鼻炎继发慢性鼻窦炎患儿作为研究对象,将其随机分为观察组(49例)和对照组(48例)。对照组患儿在糖皮质激素治疗前给予生理盐水鼻腔喷雾器,观察组患儿给予低pH缓冲生理海水鼻腔喷雾器喷雾,2组患儿均连续治疗1年。比较2组患儿治疗前及治疗4、8、12个月时鼻炎症状[视觉模拟量表(VAS)]、鼻呼吸道炎症水平[肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)、γ干扰素(IFN-γ)]及生活质量[鼻-结膜炎生活质量问卷(RQLQ)],以及不良反应发生率。结果观察组患儿治疗有效率[93.88%(46/49)]明显高于对照组[77.08%(37/48)],差异有统计学意义(P<0.05)。观察组患儿治疗4、8、12个月时VAS评分明显低于对照组,差异均有统计学意义(P<0.05)。观察组患儿治疗4、8、12个月时鼻腔分泌物或灌洗液中TNF-α、IL-17水平低于对照组,而IFN-γ水平高于对照组,差异均有统计学意义(P<0.05)。观察组患儿治疗4、8、12个月时RQLQ评分低于对照组,差异均有统计学意义(P<0.05)。观察组患儿不良反应发生率[10.20%(5/49)]高于对照组[8.33%(4/48)],但差异无统计学意义(χ^(2)=0.100,P=0.750)。结论变应性鼻炎继发慢性鼻窦炎患儿糖皮质激素治疗前使用低pH缓冲生理海水鼻腔喷雾治疗效果良好,可减轻患儿鼻炎症状及鼻呼吸道炎症水平,提升治疗效果。
Objective To investigate the effect of low pH buffered physiological seawater nasal spray on the symptoms of rhinitis and the level of nasal and respiratory inflammatory factors in children with chronic sinusitis secondary to allergic rhinitis caused by air-borne pollen.Methods A total of 97 children with allergic rhinitis secondary to chronic sinusitis admitted to our department from April 2021 to April 2023 were randomly divided into the observation group(49 cases)and the control group(48 cases).Before glucocorticoid treatment,children in the control group were given normal saline nasal sprayers,while children in the observation group were given nasal sprayers with low pH buffered normal seawater.Both groups of children were treated continuously for one year.The nasal inflammation symptoms[Visual Analogue Scale(VAS)],nasal and respiratory tract inflammation levels[tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),interferon-γ(IFN-γ)],quality of life[Naso-conjunctivitis Quality of Life Questionnaire(RQLQ)],and adverse conditions were compared between the two groups of children before treatment and at 4,8,and 12 months of treatment Reaction incidence rate.Results The effective rate of treatment in the observation group[93.88%(46/49)]was significantly higher than that in the control group[77.08%(37/48)],and the difference was statistically significant(P<0.05).The VAS scores of the children in the observation group at 4,8 and 12 months of treatment were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).At 4,8 and 12 months of treatment,the levels of TNF-αand IL-17 in nasal secretions or lavage fluid of children in the observation group were lower than those in the control group,while the level of IFN-γwas higher than that in the control group.The differences were statistically significant(P<0.05).The RQLQ scores of the children in the observation group at 4,8 and 12 months of treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group[10.20%(5/49)]was higher than that in the control group[8.33%(4/48)],but the difference was not statistically significant(χ^(2)=0.100,P=0.750).Conclusion Low pH buffered physiological seawater nasal spray before glucocorticoid therapy is effective in the treatment of children with allergic rhinitis secondary to chronic sinusitis,which can alleviate the symptoms of rhinitis and the level of nasal and respiratory inflammation in children,and improve the therapeutic effect.
作者
吴梦
崔明
陈丹丹
WU Meng;CUI Ming;CHEN Dandan(Department of Otolaryngology Head and Neck Surgery,Children's Hospital Affiliated of Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital,Zhengzhou,Henan 450000,China)
出处
《现代医药卫生》
2025年第8期1889-1893,共5页
Journal of Modern Medicine & Health
关键词
变应性鼻炎
慢性鼻窦炎
花粉
生理性海水
鼻腔冲洗
Allergic rhinitis
Chronic sinusitis
Pollen
Physiologic seawater
Nasal irrigation
作者简介
吴梦(1995-),本科,护师,主要从事耳鼻咽喉头颈外科的研究工作。
