摘要
膀胱炎是泌尿系统最常见的疾病之一,临床患者主要表现为尿频、尿急、尿痛,也被称为"膀胱刺激三联征",尤以女性多见。近年来,随着人们生活方式改变,我国膀胱疾病患病率逐年递增,该文根据膀胱炎中西医病因病机及临床病症的特点,查阅相关文献整理出临床诊断标准,通过对现有膀胱炎动物模型的分析,评价模型与临床表现吻合度,总结优缺点。发现"腹腔注射环磷酰胺"以及"弗氏完全佐剂+膀胱插管"具有较高吻合度,但也存在耗时长,费用高等不足之处。目前膀胱炎模型中诊断标准大多以西医检测指标为主,有关类型明确诊断依据还需依赖于膀胱镜检查+组织活检,因中医证候模型的缺乏也给中医药研究带来了局限性,且中医动物模型评价方法"四诊"因其易受主观因素影响,不能够很好的应用在动物模型上,可通过一些行为学测试来判定模型指标,制定相关行为参数评分量表。因此建立既符合西医临床病症特点也符合中医辨证的膀胱炎动物模型是当下所需,以更好地促进膀胱炎的研究。
Cystitis,one of the most common diseases in the urinary system,is manifested by urinary frequency,urinary urgency,and bladder pain,which are known as the classic symptom triad of bladder irritation,especially in women. In recent years,with the change of the lifestyle,the prevalence of bladder diseases in China is increasing year by year. According to the characteristics of etiology,pathogenesis,and clinical symptoms of cystitis,this paper listed the clinical diagnostic criteria in traditional Chinese medicine(TCM)and western medicine after consulting the relevant literature. Through the analysis of the existing animal model of cystitis,the fit between the model and clinical manifestations was evaluated,and the advantages and disadvantages were summarized. The models induced by "intraperitoneal injection of cyclophosphamide" and "Freund’s complete adjuvant combined with bladder catheterization" were proved highly matched with manifestations despite some shortcomings such as long time and high cost. At present,the diagnostic criteria of cystitis are mainly based on western medicine,and the definitive diagnosis of the relevant types still depends on cystoscopy and tissue biopsy. The lack of TCM syndrome model limits the TCM research. Additionally,four diagnostic methods in TCM cannot be well applied to animal models because of the susceptibility to subjective factors. Behavioral tests can be used to determine the model index and develop the relevant behavior rating scale.Therefore,it is necessary to establish an animal model of cystitis in line with the clinical characteristics of western medicine and TCM syndrome differentiation,so as to better promote the study of cystitis.
作者
谢逸轩
王赛
刘浩哲
朱飞鹏
苗明三
XIE Yi-xuan;WANG Sai;LIU Hao-zhe;ZHU Fei-peng;MIAO Ming-san(Henan University of traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第11期246-250,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局标准化项目(GZY-FJS-2020-219)
河南省药品监督管理局科技计划项目(2020DB050-55)。
关键词
膀胱炎
临床病症
动物模型
cystitis
clinical characteristics of traditional Chinese and western medicine
animal models
作者简介
第一作者:谢逸轩,在读硕士,从事药理学研究,E-mail:3072667897@qq.com;通信作者:苗明三,博士,教授,从事中药药理学研究,Tel:0371-65962546,E-mail:miaomingsan@163.com。
