摘要
目的对有关周围神经错配再生的研究进展进行综述,为相关基础研究及临床治疗提供参考。方法查阅近年国内外相关研究文献,总结周围神经损伤后的病理生理、影响周围神经错配再生的几个主要因素以及轴突错配再生后的结局。结果远端神经通路及靶器官可以选择性影响周围神经的错配再生;不同表型雪旺细胞对周围神经错配再生的影响不同;研究不同细胞来源外泌体对不同类型轴突的作用机制,可为解决周围神经错配再生提供新的方向和思路。结论周围神经的错配再生受多种因素影响,但这些因素的具体作用机制和规律特点有待进一步研究和探讨。
Objective To review the research progress of peripheral nerve mismatch regeneration,and to provide reference for its related basic research and clinical treatment.Methods The pathophysiology of peripheral nerve after injury,several main factors affecting the mismatch regeneration of peripheral nerve,and the fate of axon after mismatch regeneration were summarized by referring to the relevant literature at home and abroad in recent years.Results Distal pathways and target organs can selectively affect the mismatch regeneration of peripheral nerves;different phenotypes of Schwann cells have different effects on the mismatch regeneration of peripheral nerves;studying the mechanism of action of exosomes from different Schwann cells on different types of axons can provide a new direction for solving the mismatch regeneration of peripheral nerves.Conclusion Peripheral nerve mismatch regeneration is affected by various factors.However,the specific mechanism and characteristics of these factors remain to be further studied.
作者
王坤靓
秦本刚
WANG Kunliang;QIN Bengang(Department of Microsurgery,Orthopaedic Trauma and Hand Surgery,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou Guangdong,510080,P.R.China)
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2021年第3期387-391,共5页
Chinese Journal of Reparative and Reconstructive Surgery
基金
广东省自然科学基金面上项目(2019A1515012057)。
关键词
周围神经
错配再生
神经损伤
神经功能恢复
Peripheral nerve
mismatch regeneration
nerve injury
recovery of nerve function
作者简介
通信作者:秦本刚,Email:qinbeng@mail.sysu.edu.cn。
