摘要
背景:一直以来周围神经损伤在临床工作中十分常见,虽然显微外科技术能很好地恢复损伤神经的连续性,但是由于周围神经组织存在分化程度较高、再生能力较低的特点,使得神经修复效果仍不理想,严重影响患者的生活质量。目前周围神经损伤微环境尚无统一定论,常用的修复方式众多。目的:对周围神经损伤微环境及周围神经损伤修复方式进行综述。方法:第一作者应用计算机检索1964年1月至2019年9月中国知网、PubMed数据库的相关文章,英文检索词为"peripheral nerve injury,microenvironment,microsurgical technique,small gap bridging",中文检索词为"周围神经损伤修复,微环境,显微外科技术,小间隙套接法",最终选择57篇文献进行综述。结果与结论:①经过一系列动物实验和临床研究,神经再生通道的建立、神经营养因子、免疫反应、炎症反应、激素调节等微环境变化已被证实是影响周围神经修复的重要因素;②生物套管小间隙套接法修复周围神经损伤具备替代临床常用的传统神经外、束膜的可行性。
BACKGROUND:Peripheral nerve injury has been very common in clinical work.Although microsurgical technique can restore the continuity of the injured nerve well,the nerve repair effect is still unsatisfactory due to the high degree of differentiation and low regeneration ability of the peripheral nerve tissue,which seriously affects the quality of life of patients.At present,there is no unified conclusion on the microenvironment of peripheral nerve injury,and there are many repair methods in common use.OBJECTIVE:To review the microenvironment of peripheral nerve injury and the repair methods of peripheral nerve injury.METHODS:A computer-based online search of PubMed and CNKI databases was performed for the articles published from January 1964 to September 2019.The key words were“peripheral nerve injury;microenvironment;microsurgical technique;small gap bridging”in English and Chinese,respectively.Finally,57 eligible articles were included to review.RESULTS AND CONCLUSION:(1)After a series of animal experiments and clinical studies,changes in microenvironment such as the establishment of nerve regeneration channels,neurotrophic factors,immune response,inflammatory response,and hormone regulation have been confirmed to be important factors affecting peripheral nerve repair.(2)It is feasible to repair the peripheral nerve injury by using biological conduit small gap bridging instead of the traditional external and fascicular membrane.
作者
宋凯凯
张锴
贾龙
Song Kaikai;Zhang Kai;Jia Long(Department of Orthopedic Trauma,Affiliated Hospital of Binzhou Medical College,Binzhou 256600,Shandong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第4期651-656,共6页
Chinese Journal of Tissue Engineering Research
基金
山东省医药卫生科技发展计划项目(2016WS0040),课题名称:周围神经损伤修复微环境生理能量代谢研究,项目负责人:贾龙。
关键词
实验
因子
周围神经
修复
微环境
外膜
束膜
显微外科技术
综述
experiment
factor
peripheral nerve
repair
microenvironment
adventitia
fascicle
microsurgical technique
review
作者简介
第一作者:宋凯凯,男,1993年生,山东省惠民县人,汉族,滨州医学院在读硕士,主要从事创伤骨科研究,https://orcid.org/0000-0002-7349-7906;通讯作者:贾龙,硕士,副教授,滨州医学院附属医院创伤骨科,山东省滨州市256603。
