摘要
目的运用“中医传承辅助平台管理系统(V2.5)”探讨中医药治疗卒中后抑郁的用药规律。方法收集中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普(VIP)、万方数据知识服务平台(Wanfang Data)中关于中医药治疗卒中后抑郁的相关文献,检索时限为建库至2020年2月,将筛选后的有效方剂录入中医传承辅助平台,建立治疗卒中后抑郁的组方数据库,采用关联规则、复杂系统熵聚类、无监督熵层次聚类等数据挖掘方法对其进行分析。结果共收集269首有效方剂,涉及中药177味,药性以温、寒、平为主;药味以苦味、辛味为主,甘味次之,药物归经以肝、心、脾为主;药物频次≥57的中药18味,居于前5位的中药分别是柴胡、郁金、川芎、当归、白芍;核心药物组居于前5位的分别是川芎-柴胡、郁金-柴胡、当归-柴胡、白芍-柴胡、柴胡-茯苓;通过复杂系统熵聚类得到14对核心药物组合、7首新方。结论治疗卒中后抑郁多使用疏肝健脾类中药,常配伍理气、养心安神之品,同时注重诊治兼症。
Objective To explore the medication rules of traditional Chinese medicine in treating poststroke depression by“traditional Chinese medicine inheritance support system(V2.5)”.Methods The literatures related to the treatment of poststroke depression with traditional Chinese medicine in CNKI,CBM,VIP and Wanfang Data were collected,the time limit for retrieval was from inception to February 2020.The effective prescriptions after screening were entered into the traditional Chinese medicine inheritance support system,to establish a prescription database for treating poststroke depression.Data mining methods such as association rules,complex system entropy clustering and unsupervised entropy hierarchical clustering were used to analyze the data.Results A total of 269 effective prescriptions were included,involving 177 kinds of Chinese medicine.The main nature of drugs were warm,cold and calm,and the main flavors were bitter and pungent,followed by the sweet.The main drugs were belonged to liver,heart and spleen channels.Eighteen kinds of Chinese medicine with a frequency more than 57.The top five Chinese medicines were Radix Bupleuri,Radix Curcumae,Rhizoma Ligustici Chuanxiong,Radix Angelicae Sinensis and Radix Paeoniae Alba.The top five core drug combinations were Rhizoma Ligustici Chuanxiong-Radix Bupleuri,Radix Curcumae-Radix Bupleuri,Radix Angelicae Sinensis-Radix Bupleuri,Radix Paeoniae Alba-Radix Bupleuri,Radix Bupleuri-Poria.Fourteen core drug combinations and seven new prescriptions were obtained through complex system entropy clustering.Conclusion In the treatment of poststroke depression,traditional Chinese medicine for dispersing the stagnated liver-energy and invigorating the spleen is often used,which is often combined with the products for regulating vital energy,nourishing the heart and calming the nerves.
作者
袁敏皎
袁捷
韩祖成
YUAN Minjiao;YUAN Jie;HAN Zucheng(The First Clinical Medical College,Shaanxi University of Chinese Medicine,Shaanxi Province,Xianyang712000,China;Department of Encephalopathy,Shaanxi Hospital of Traditional Chinese Medicine,Shaanxi Province,Xi’an710000,China)
出处
《中国医药导报》
CAS
2021年第5期159-162,共4页
China Medical Herald
基金
国家中医药管理局中医药行业科研专项项目(201507001-05)
陕西省中医医院院级科研课题(2019-02)。
关键词
中医传承辅助平台
卒中后抑郁
方剂
用药规律
Traditional Chinese medicine inheritance support system
Poststroke depression
Prescriptions
Medication rule
作者简介
袁敏皎(1992-),女,陕西中医药大学第一临床医学院2018级中医内科学专业在读硕士研究生,研究方向:中医脑病;通讯作者:韩祖成(1961-),男,硕士,主任医师,硕士生导师,陕西省中医医院脑病二科主任,研究方向:中医内科脑病、神志病。
