摘要
目的探讨胡国俊教授辨治慢性咳嗽的处方用药规律,传承名医经验。方法收集胡国俊教授临床治疗慢性咳嗽的临床方药,将数据统计整理后,采用频数统计、聚类分析和因子分析的方法进行数据挖掘,总结其治疗慢性咳嗽的用药规律。结果共收集到有效方剂205首,涉及中药107味。胡国俊教授治疗慢性咳嗽使用的高频药物包括僵蚕、蝉蜕、麻黄、黄芩、甘草、苦杏仁、枇杷叶等,共计38味,出现频次占86.46%。按功效大致可归为化痰止咳平喘药、解表药、补虚药、清热药、平肝熄风药等10类。聚类分析得出僵蚕-蝉蜕-甘草-赤芍-旋覆花,麻黄-苦杏仁-桔梗等6个聚类方。因子分析得出葶苈子-薏苡仁-冬瓜子-芦根,麻黄-苦杏仁-桔梗-半夏等10个公因子。结论胡国俊教授辨治慢性咳嗽重视肺脾不足、风痰内扰的病机,治疗多从风、痰、热入手,多以祛风解痉、清肺化痰、疏风宣肺为大法,兼以补肺、健脾、化瘀、敛肺等;用药重视补肺气肺阴,健脾气与补胃阴相结合,攻补兼施,苦辛并进,寒温并用,为临床治疗和研究慢性咳嗽提供思路和借鉴。
Objective To explore Professor Hu Guojuns medication rule in treating chronic cough and summarize his clinical experience. Methods Prescriptions for treating chronic cough by professor Hu Guojun were collected. The relation between the medicinals involved was analyzed by using frequency statistics, cluster analysis and factor analysis methods to carry out data mining. Results A total of 205 effective prescriptions were collected, involving 107 medicinals. Medicinals frequently used in treating chronic cough included Bombyx Batryticatus, Periostracum Cicada,Herba Ephedrae, Radix Scutellariae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Folium Eriobotryae, etc., with a total of 38 flavors and 86.46% of the frequency, which could be roughly classified as 10 categories, including expectorant cough suppressants and anti-asthmatic medicinals, diaphoretic medicinals, tonic medicinals, heat-clearing medicinals,liver wind calmed medicinals and other categories according to the efficacy. Cluster analysis resulted in 6 clusters, such as Bombyx Batryticatus + Periostracum Cicada + Radix Glycyrrhizae + Radix Paeoniae Rubra + Flos Inulae, Herba Ephedrae + Semen Armeniacae Amarum + Radix Platycodonis. Factor analysis showed 10 common factors, such as Semen Descurainiae + Semen Coicis + Semen Benincasae + Rhizoma Phragmitis, Herba Ephedrae + Semen Armeniacae Amarum+ Radix Platycodonis + Rhizoma Pinelliae. Conclusion Professor Hu Guojun paid attention to the pathogenesis of deficiency of lung and spleen and disturbance of wind and phlegm in the treatment of chronic cough, starting with wind,phlegm and heat. The treatment mainly focused on eliminating wind and spasm, clearing lung and phlegm, dispersing wind and promoting lung, and also on nourishing lung, spleen, blood stasis and lung. The medication rule focused on nourishing Lung qi, lung yin, spleen qi and stomach yin, combined with attack and supplement, bitterness and acridity,and cold and warm for clinical treatment and research.
作者
戴广川
高雅婷
吴迪
韩磊玲
朱慧志
Dai Guangchuan;Gao Yating;Wu Di;Han Leiling;Zhu Huizhi(Department of Tuberculosis,The Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing 210000,China;Graduate School,Anhui University of Chinese Medicine,Hefei 230012,China;Department of Respiratory,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第12期4219-4224,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
安徽省人力资源和社会保障厅科学带头人支撑项目(2014H028):胡国俊全国名老中医药专家传承工作室建设项目(2013),负责人:朱慧志。
关键词
慢性咳嗽
数据挖掘
用药规律
名医经验
Chronic cough
Data mining
Medication rule
Clinical experience of famous doctors
作者简介
通讯作者:朱慧志,主任医师,医学博士,主要研究方向:中医药防治呼吸系统疾病研究。
