摘要
目的:探讨糖化血红蛋白(HbA1c)检测在2型糖尿病(DM)合并小细胞性贫血诊断中的应用价值。方法:对34例合并小细胞性贫血的2型DM病人(小细胞贫血组)、34例正细胞性贫血的2型DM病人(正细胞贫血组)、48例非贫血2型DM病人(单纯2型DM组)及68名健康体检者(健康对照组),分别检测HbA1c、空腹血糖(FPG)、血红蛋白(Hb)和平均红细胞体积(MCV)水平,分析HbA1c与FPG的相关性。结果:4组HbA1c、FPG、Hb、MCV检测结果比较,差异均有统计学意义(P<0.01)。正细胞贫血组和单纯2型DM组HbA1c与FPG存在正相关(r=0.708、0.773,P<0.05),小细胞贫血组HbA1c与FPG无相关性(r=0.302,P>0.05)。结论:2型DM合并小细胞性贫血病人HbA1c水平不能准确反映病人体内血糖真实水平。
Objective:To explore the value of glycosylated hemoglobin(HbA1c)level in the diagnosis of type 2 diabetes mellitus complicated with microcytic anemia.Methods:The levels of HbA1c,FPG,Hb and MCV in 34 patients with type 2 diabetes mellitus complicated with microcytic anemia(microcytic anemia group),34 patients with type 2 diabetes mellitus complicated with normocytic anemia(normocytic anemia group),48 patients with type 2 diabetes mellitus complicated without anemia(simple type 2 DM group)and 68 healthy people(healthy control group)were detected.The correlation between HbA1c and FPG was analyzed.Results:The differences of the levels of HbA1c,FPG,Hb and MCV among four groups were statistically significant(P<0.01).The HbA1c level was positive correlation with FPG in normocytic anemia group and single type 2 DM group(r=0.708,r=0.773,P<0.05),but the HbA1c level was not correlation with FPG in microcytic anemia group(r=0.302,P>0.05).Conclusions:The HbA1c level in type 2 diabetes mellitus patients with microcytic anemia can not accurately reflect the real level of blood glucose.
作者
张国良
高云龙
ZHANG Guo-liang;GAO Yun-long(Department of Laboratory,Tianchang Hospital of Traditional Chinese Medicine,Tianchang Anhui 239300;Department of Laboratory Medicine,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou Guangdong 510120,China)
出处
《蚌埠医学院学报》
CAS
2020年第8期1094-1096,共3页
Journal of Bengbu Medical College
基金
广东省中医药局资助项目(20182055)。
关键词
糖尿病
糖化血红蛋白
小细胞性贫血
diabetes mellitus
glycosylated hemoglobin
microcytic anemia
作者简介
张国良(1984-),男,主管技师。
