摘要
目的:为明确妊娠期糖尿病(gestational diabetes mellitus,GDM)患者血清糖化血红蛋白(glycosylated hemoglobin,Hb A1c)与C反应蛋白(C-reactive protein,CRP)的关系,本研究检测了GDM患者血糖、血清Hb A1c与CRP水平,并对Hb A1c与CRP的相关性进行了分析。方法:以68例2015年4月至2017年4月于我院诊治的GDM孕妇为研究对象,所有患者均符合《妇产科学》中关于GDM的诊断标准,另选取68例正常孕妇为对照组。采用葡萄糖氧化酶法检测血糖水平(空腹血糖及餐后2 h血糖水平),采用免疫凝集法检测和比较两组血清糖化血红蛋白(HbA1c)水平,采用免疫透射比浊法检测血清C反应蛋白(CRP)水平,并分析HbA1c与CRP的相关性。结果:GDM组患者空腹血糖(fasting plasma glucose,FPG)、2 h血糖(plasma glucose,PG)、血清HbA1c和CRP水平均显著高于正常组(P<0.05),GDM患者血清Hb A1c和CRP水平呈显著正相关关系(r=0.654,P<0.05)。结论:GDM患者血清HbAlC和CRP水平相较于正常孕妇有显著提高,且二者呈显著的正相关关系,二者联合检测可能作为GDM早期诊断的筛查的重要参考指标。
Objective： To determine the relationship between serum glycosylated hemoglobin（Hb A1 c） and C-reactive protein（CRP） in patients with gestational diabetes mellitus（GDM）. In this study, blood glucose levels, serum Hb A1 c and CRP were measured in patients with GDM and the correlation between Hb A1 c and CRP was studied. Methods： A total of 68 pregnant women with gestational diabetes mellitus diagnosed and treated in our hospital from April 2015 to April 2017 were selected as research objects. All patients were in line with ＂Obstetrics and Gynecology＂ in the diagnostic criteria for GDM, and the other 68 normal pregnant women as the control group. There was no significant difference between the two groups in the general information of the study subjects, and the inclusion and exclusion criteria were met. Glucose oxidase method was used to test the blood glucose level（fasting blood glucose and postprandial 2 h blood glucose level）. Immunoagglutination method was used to detect serum Hb A1 c, Immunoturbidimetry was used to detect the C-reactive protein（CRP）. The differences between the two groups were compared, and the correlation between Hb A1 c and CRP was studied.All data were analyzed by SPSS 20.0, t-test and correlation analysis were used to analyze the data. The difference was statistically significant at P〈0.05. Results： The levels of fasting plasma glucose（FPG） and 2 h plasma glucose（PG） in GDM pregnant women and normal pregnant women were significantly higher than those in normal controls（P〈0.05）. In this study, serum levels of Hb A1 c and CRP were measured in patients with GDM and normal controls. The levels of Hb A1 c and CRP in patients with GDM were significantly higher than those in normal controls（P〈0.05）. Correlation analysis of serum Hb A1 c level and CRP level in pregnant women with GDM showed that there was a significant positive correlation between Hb A1 c and CRP levels in GDM patients（r=0.654, P〈0.05）. Conclusions： The serum Hb Al C and CRP levels were significantly upregulated in GDM patients. There was a significant positive correlation between serum Hb A1 c and CRP levels in GDM patients. Combined detection of serum Hb Al C and CRP levels couls be used as an important indicator of early diagnosis of GDM.
作者
闫学平
胡敬
郝秀丽
孙婷
齐如艳
李绍刚
郭建巍
YAN Xue-ping;HU Jing;HAO Xiu-li;SUN Ting;QI Ru-yan;LI Shao-gang;GUO Jian-wei(Clinical Laboratory, The First Hospital of Integrated Chinese and Western Medicine of Beijing, City/First Affiliated Hospital of Chinese Academy of Traditional Chinese Medicine, Chinese Academy of Medical Sciences, Beijing, 100018, China;Obstetn＇cs and Gynecology, The First Hospital of Traditional Chinese Medicine and Western Medicine of Beijing City, Beijing, 100018, China;Pediatric Department, The First Hospital of Integrated Chinese and Western Medicine of Beijing City/First Affiliated Hospital of Chinese Academy of Traditional Chinese Medicine, Chinese Academy of Medical Sciences, Beijing, 100018, China)
出处
《现代生物医学进展》
CAS
2018年第9期1701-1704,共4页
Progress in Modern Biomedicine
基金
国家卫生计生委临床科研专项(W2016EWQT39)
关键词
妊娠糖尿病
血糖
糖化血红蛋白
C反应蛋白
相关性
Gestational diabetes
Blood glucose
Glycosylated hemoglobin
C-reactive protein
Correlation
作者简介
闫学平（1965-），女，专科，主管技师，研究方向：临检，生化，血库，免疫等，E-mail：yanxueping_1965@papmedline．cn;通讯作者：郭建巍（1965-），男，博士，主任检验师，研究方向：病原微生物及分子诊断学，E-mail：guojianwei_1965@papmedline．cn
