摘要
目的:探讨骨化三醇治疗女性绝经后骨质疏松性髋部骨折的效果及对骨代谢水平、骨密度影响。方法:选取某院2017年1月~2018年1月收治的120例绝经后骨质疏松性髋部骨折患者为研究对象,采用随机数字表方法分为治疗组和对照组各60例,对照组予以常规治疗,治疗组在对照组的基础上予以骨化三醇口服,两组均治疗9个月,比较两组的骨痛情况、治疗前后的骨代谢水平[骨型碱性磷酸酶(BALP)、抗酒石盐酸性磷酸酶异构体(TRACP-5b)]及骨密度。结果:治疗组的疼痛分级明显优于对照组(P<0.05);治疗组的BALP、TRACP-5b水平显著低于对照组(P<0.05);治疗组的骨密度显著大于对照组(P<0.05)。结论:骨化三醇治疗绝经后骨质疏松性髋部骨折能够明显改善骨痛症状,提高骨密度及骨强度。
Objective:To explore the effects of calcitriol on postmenopausal osteoporotic hip fracture in women and its influence on bone metabolism level and bone mineral density. Methods:120 patients with postmenopausal osteoporotic hip fracture who were admitted to a hospital from January 2017 to January 2018 were selected for the study and were divided into treatment group(60 cases) and control group(60 cases) according to the random number table method. Control group was given routine therapy, and treatment groupwas given calcitriol orally on the basis of control group,and the two groups were treated for 9 months.The bone pain conditions,and bone metabolism [bone alkaline phosphatase(BALP),tartrate-resistant acid phosphatase(TRACP-5 b)]and bone mineral density before and after treatment were compared between the two groups.Results:The pain grade in treatment group was significantly better than that in control group(P<0.05).The levels of BALP and TRACP-5 bin treatment group were significantly lower than those in control group(P<0.05).The bone mineral density in treatment group was significantly higher than that in control group(P<0.05).Conclusion:Calcitriol can significantly improve the symptoms of bone pain and increase the bone density and bone strength in the treatment of postmenopausal osteoporotic hip fracture.
作者
张俊海
Zhang Junhai(Department of Orthopedics,Yongcheng Central Hospital,Shangqiu 476600)
出处
《数理医药学杂志》
2020年第5期766-768,共3页
Journal of Mathematical Medicine
作者简介
张俊海(1980-),男,汉族,本科,主治医师。
