摘要
肌少-骨质疏松症是一种肌少症和骨质疏松症并存的退行性代谢综合征,常发生在老年人身上。其特点是骨密度低、肌肉质量下降和力量损失,这些因素会降低生活质量和活动能力。肌肉骨骼系统是人类整体健康的重要决定因素,随着人口老龄化,肌少-骨质疏松症患者日益增多,其治疗方法越来越受到重视。人体肠道中存在一个复杂的菌群,这些菌群影响着肌肉骨骼发育和体内平衡。因此本综述以肠道菌群对肌肉、骨骼的作用为切入点,分析肠道菌群在肌少-骨质疏松症发病机制及治疗中的作用,阐明肌少-骨质疏松症与肠道菌群的相关性,为更好地治疗肌少-骨质疏松症提供新思路。
Sarcopenia-osteoporosis is a degenerative metabolic syndrome in which sarcopenia and osteoporosis coexist,often in the elderly.It is characterized by low bone density,decreased muscle mass and loss of strength,factors that can reduce quality of life and mobility.The musculoskeletal system is an important determinant of overall human health,and as the population ages,the number of patients with sarcopenia-osteoporosis is increasing and its treatment is receiving increasing attention.A complex flora exists in the human gut and these flora influence musculoskeletal development and homeostasis in vivo.Therefore,this review takes the role of intestinal flora on muscle and bone as an entry point to analyze the role of intestinal flora in the pathogenesis and treatment of sarcopenia-osteoporosis,to elucidate the correlation between sarcopenia-osteoporosis and intestinal flora,and to provide new ideas for better treatment of sarcopenia-osteoporosis.
作者
魏巍
王世轩
战丽彬
WEI Wei;WANG Shixuan;ZHAN Libin(The Second Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China;Innovation Engineering Technology Center,Liaoning University of Chinese Medicine,Shenyang 110000,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2024年第9期2434-2443,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家中医药管理局全国名老中医药专家传承工作室(国中医药人教函(2022)75号):2022王世轩全国老中医药专家传承工作室建设项目,负责人:王世轩
辽宁省科学技术厅博士科研启动基金计划项目(2023-BS-050):基于“骨肉不相亲”理论探讨骨疏康调控Pi3k-Akt-Bad通路防治“肌少-骨质疏松症”的机制研究,负责人:魏巍。
关键词
肌少-骨质疏松症
肠道菌群
干预方式
研究进展
Sarcopenia-osteoporosis
Intestinal flora
Intervention modality
Research progress
作者简介
通讯作者:王世轩,教授/主任医师,博士研究生导师,博士后合作导师,主要研究方向:骨质疏松症、骨坏死及骨性关节炎。
