摘要
自闭症谱系障碍(ASD)是一种严重的因神经系统失调导致的发育障碍,尽管目前对其病因及病理机制尚不十分清楚,但临床上可观察到ASD患儿常表现出胃肠道(GI)问题和免疫失调等症状。研究表明,肠道菌群及其代谢产物不仅与GI问题有关,还与ASD的行为症状有关。此外,母体感染也可能会增加后代患ASD风险。笔者现围绕肠道菌群影响ASD的可能机制以及几种与肠道菌群有关的可能治疗儿童ASD的方法进行综述,以期为治疗或预防儿童ASD提供新的思路。
Autism spectrum disorder(ASD)is a serious neurodevelopmental disorder.Although its etiology and mechanism are still unclear,children with ASD often show gastrointestinal problems and immune disorders.Studies have shown that intestinal flora and its metabolites are not only associated with gastrointestinal problems,but also with autistic behavioral symptoms.In addition,maternal infections may increase the risk of ASD in offspring.This review focuses on the possible mechanism of intestinal flora influencing ASD and several possible methods related to intestinal flora for treatment of ASD in children,in order to provide new ideas for the treatment or prevention of autism children.
作者
邹荣
郑华军
Zou Rong;Zheng Huajun(Institute of Reproduction and Development,Fudan University,Shanghai Institute of Family Planning Science,Shanghai 200032,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2020年第3期320-324,共5页
Chinese Journal of Neuromedicine
关键词
肠道菌群
自闭症谱系障碍
儿童
“脑-肠-菌”轴
Intestinal flora
Autism spectrum disorder
Children
Brain-intestine-bacteria axis
作者简介
通信作者:郑华军,Email:zhenghj@sippr.org.cn。
