摘要
目的评价单唾液酸四己糖神经节苷脂对急性脑梗死患者血清超敏C反应蛋白(hs-CRP)、星形细胞钙结合蛋白(S100β蛋白)的影响。方法2018年6月—2019年5月间收治的60例急性脑梗死患者被随机分为对照组(30例)和观察组(30例)。对照组给予常规治疗(如抗血小板聚集、改善循环、调控血脂、血压及血糖等),观察组在常规治疗基础上采用单唾液酸四己糖神经节苷脂治疗。治疗2周,比较两组神经功能缺损(NIHSS评分)、血清hs-CRP、S100β蛋白水平及不良反应发生情况。结果治疗后,观察组hs-CRP水平(4.50±1.97)mg/L、S100β蛋白水平(0.31±0.08)μg/L及NIHSS评分(9.13±2.40)分均明显低于对照组(5.83±2.50)mg/L、(0.38±0.10)μg/L、(10.83±3.23)分(t=2.283,P=0.030;t=2.698,P=0.011;t=2.307,P=0.028),且未发现明显不良反应。结论单唾液酸四己糖神经节苷脂能有效降低急性脑梗死患者血清hs-CRP、S100β蛋白水平,促进脑神经功能修复。
Objective To evaluate the effects of monosialotetrahexosylganglioside on serum high-sensitivity C-reactive protein(hs-CRP)and astrocyte calcium-binding protein(S100βprotein)in patients with acute cerebral infarction.Methods Sixty patients with acute cerebral infarction admitted between June 2018 and May 2019 were randomly divided into control group(30 cases)and observation group(30 cases).The control group received conventional treatment(such as anti-platelet aggregation,improved circulation,regulation of blood lipids,blood pressure and blood glucose,etc.),and the observation group was treated with monosialotetrahexosyl ganglioside on the basis of conventional treatment.After 2 weeks of treatment,the neurological deficits(NIHSS score),serum hs-CRP,S100βprotein levels and adverse reactions were compared between the two groups.Results After treatment,hs-CRP levels(4.50±1.97)mg/L,S100βprotein levels(0.31±0.08)μg/L and NIHSS scores(9.13±2.40)points were significantly lower in the observation group than in the control group(5.83±2.50)mg/L,(0.38±0.10)μg/L,(10.83±3.23)points(t=2.283,P=0.030;t=2.698,P=0.011;t=2.307,P=0.028),and no significant adverse reactions were observed.Conclusion Monosialotetrahexosylganglioside can effectively reduce serum hs-CRP and S100βprotein levels in patients with acute cerebral infarction and promote the repair of brain nerve function.
作者
韩林燕
HAN Lin-yan(Department of Neurology,Nantong Elderly Rehabilitation Hospital,Nantong,Jiangsu Province,226001 China)
出处
《系统医学》
2019年第23期48-50,共3页
Systems Medicine
作者简介
韩林燕(1983-),女,江苏南通人,本科,主治医师,研究方向:神经内科学。
