摘要
目的:观察补肾调肝生精汤在治疗肾虚肝郁型特发性弱精子症有效性与安全性。方法:选取2016年6月至2016年11月中国中医科学院西苑医院男科门诊收治的特发性弱精子症辨证属于肾虚肝郁证患者66例作为研究对象,随机分为2组,每组33例。观察组给予补肾调肝生精汤免煎颗粒,每天1剂,早晚各1袋;对照组给予左卡尼汀口服液3次/d,1支/次。2组均连续治疗12周后评价临床疗效,比较2组治疗前后PR级、PR+NP级精子活力、中医症状积分,同时观察药物的安全性。结果:对2组治疗后进行比较,发现治疗第4周、8周时2组在改善患者PR级和PR+NP精子方面没有统计学意义(P>0.05);治疗12周时2组PR和PR+NP精子改善存在统计学意义(P<0.05),且观察组疗效较为显著;中医症状积分较前有改善,且观察组均优于对照组(P<0.05)。2组均未发生明显不良反应。结论:观察组在提高PR精子、精子总活力及改善中医症状方面优于对照组(P<0.05)。说明补肾调肝生精汤在治疗肾虚肝郁型特发性弱精子症方面疗效较好,值得临床推广应用。
Objective:To observe the efficacy and safety of Bushen Tiaogan Shengjing Decoction in the treatment of idiopathic asthenospermia of kidney-deficiency and liver-depression syndrome.Methods:A total of 66 patients with idiopathic asthenospermia of kidney-deficiency and liver-depression syndrome in Xiyuan Hospital,China Academy of Chinese Medical Sciences from June to November 2016 were randomly divided into a control group and an observation group according to random number table,with 33 cases in each group.The control group was given Levocarnitine Oral Solution,1 bottle at a time,3 times a day.The observation group was given Bushen Tiaogan Shengjing Decoction,1 dose per day,1 bag each morning and evening.The clinical efficacy was evaluated after 12 weeks of continuous treatment in both groups.The sperm motility(PR,PR+NP)and TCM symptom scores were compared before and after the treatment,and the safety of the medicine was observed.Results:By comparing the 2 groups after treatments,it was found that there was no statistically significant difference between the 2 groups in improving the PR,PR+NP sperm at the 4th and 8th week of treatment(P>0.05).owever,a significant difference was found in the improvement of PR,PR+NP sperm at the 12th week of treatment(P<0.05),and the observation group was more effective.The scores of TCM symptoms were better than before,and the observation group was better than the control group(P<0.05).No significant adverse reactions occurred in either group.Conclusion:The observation group is better than the control group in improving the sperm motility rate,the quality of semen,and TCM symptoms(P<0.05),indicating that Bushen Tiaogan Shengjing Decoction has better curative effects in treating kidney-deficiency and liver-depression syndrome of idiopathic asthenospermia and it is worthy of clinical application.
作者
张继伟
高庆和
晏斌
邱俊峰
刘煜
刘胜京
王福
Zhang Jiwei;Gao Qinghe;Yan Bin;Qiu Junfeng;Liu Yu;Liu Shengjing;Wang Fu(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《世界中医药》
CAS
2019年第10期2728-2731,共4页
World Chinese Medicine
基金
中国中医科学院西苑医院苗圃课题[XYKY-(2013)-8]
关键词
男性不育症
肾虚肝郁证
补肾调肝生精汤
左卡尼汀
Male infertility
Kidney-deficiency and liver-depression syndrome
Bushen Tiaogan Shengjing Decoction
Levocarnitine
作者简介
张继伟(1989.08—),男,博士研究生在读,研究方向:中西医结合男科病防治,E-mail:984567166@qq.com;通信作者:王福(1982.01—),男,博士,主治医师,研究方向:从事中西医结合男科临床及科研工作,E-mail:fu311306@163.com。
