摘要
目的:探讨布地奈德联合硫酸沙丁胺醇短期雾化吸入用于长期控制不佳老年哮喘患者的疗效及安全性。方法:选取2014年1月至2016年9月赣州市南康区第一人民医院收治的长期控制不佳老年哮喘患者78例,以随机数字表法分为A组和B组,每组39例。A组患者给予布地奈德福莫特罗粉吸入剂常规吸入治疗,B组患者给予吸入用布地奈德混悬液+吸入用硫酸沙丁胺醇溶液短期雾化吸入治疗。观察两组患者呼吸指标、哮喘发作次数、住院时间及不良反应发生情况。结果:治疗后,A组患者呼气峰流速变化值明显高于B组,哮喘急性发作次数、日平均使用缓解药物次数明显多于B组;A组患者平均住院时间为(9.57±0.47)d,明显长于B组的(7.69±0.28)d;A组患者不良反应发生率为20.51%(8/39),明显高于B组的5.13%(2/39),上述差异均有统计学意义(P<0.05)。结论:相较于常规的干粉吸入给药,布地奈德联合硫酸沙丁胺醇短期雾化吸入有利于改善长期控制不佳老年哮喘患者的病情,降低呼气峰流速变化值,且安全性高。
OBJECTIVE： To probe into the efficacy and safety of short-term inhalation of glucocorticoid and bronchodilator in treatment of long-term poor control of elderly patients with asthma. METHODS： 78 elderly patients with asthma in long-term poor control admitted into Ganzhou Nankang District the First People＇s Hospital from Jan.2014 to Sept. 2016 were extracted to be divided into group A and group B via the random number table,with 39 cases in each. Patients in group A was given conventional inhalation（ budesonide momotrol powder inhaler）,while group B received short-term aerosol inhalation（ budesonide suspension for inhalation ＋ salbutamol sulfate solution for inhalation）. The respiratory indicators,number of asthma attacks,length of stay,and incidence of adverse drug reactions were observed in two groups. RESULTS： After treatment,the changes of PEF of group A was significantly higher than that of group B; the number of acute asthma attacks and average daily use of relief drugs of group A were significantly higher than those of group B; the average length of stay in group A was（ 9. 57 ± 0. 47） d,significantly longer than that in group B [（ 7. 69 ± 0. 28） d]; the incidence of adverse drug reactions in group A was 20. 51%（ 8/39）,significantly higher than 5. 13% in group B（ 2/39）,the above differences were statistically significant（ P〈0. 05）. CONCLUSIONS： Compared with conventional dry powder inhalation,short-term aerosolization of budesonide and salbutamol sulfate is beneficial to improve the condition of elderly patients with asthma in long-term poor control and reduce the value of PEF with higher safety.
作者
明荣幸
袁明
刘先奎
朱启城
MING Rongxin;YUAN Ming;LIU Xiankui;ZHU Qicheng(Dept.of Respiratory Medicine,Ganzhou Nankang District the First People＇s Hospital,Jiangxi Ganzhou 341400,China)
出处
《中国医院用药评价与分析》
2018年第9期1203-1204,1207,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
短期雾化吸入
糖皮质激素
支气管扩张剂
长期控制不佳
老年哮喘
Short-term atomization inhalation
Glucocorticoids
Bronchodilators
Long-term poor control
Elderly patients with asthma
作者简介
明荣幸,主治医师。研究方向:支气管哮喘、慢性阻塞性肺疾病。E-mail:xyd226@163.com
