摘要
目的探讨哮喘长期控制不佳患者应用糖皮质激素联合支气管扩张剂治疗的临床作用。方法选择我院2018年1月至2020年6月收治的100例哮喘长期控制不佳患者,以随机数表法分为两组,对照组采用支气管扩张剂治疗,观察组加用糖皮质激素联合治疗。比较两组的治疗效果。结果观察组总有效率为98.00%,高于对照组的80.00%(P<0.05);两组治疗前ACT评分、血清IL-8、IL-4比较,差异无统计学意义(P>0.05);治疗后观察组ACT评分、血清IL-8、IL-4分别为(4.32±0.42)分、(12.10±3.42)ng/L、(70.69±5.94)ng/L,对照组分别为(3.41±0.55)分、(18.75±5.43)ng/L、(90.04±6.85)ng/L,两组比较,差异均有统计学意义(P<0.05)。结论哮喘长期控制不佳应用糖皮质激素联合支气管扩张剂治疗可提高疗效,更好地改善ACT评分与血清炎性指标。
Objective To explore the clinical efficacy of glucocorticoid combined with bronchodilator in the treatment of asthma patients with long term poor control.Methods A total of 100 asthma patients with long term poor control admitted to and treated in our hospital from January 2018 to June 2020 were selected for research,and they were divided into the control group(n=50)and the observation group(n=50)according to the random number table method.The control group was treated with bronchodilator,while the observation group was treated with glucocorticoid on the basis of the control group.The clinical efficacies of the two groups were appraised,the asthma control test(ACT)scores before and after treatment were evaluated,the levels of serum interleukin-4(IL-4)and interleukin-8(IL-8)before and after treatment were detected,and the results between the two groups were compared and analyzed.Results The total effective rate of the observation group was 98.00%,which was higher than 80.00% of the control group(P<0.05).Before treatment,there was no statistically significant differences in ACT scores,levels of serum IL-4 and IL-8 between the two groups(P>0.05).After treatment,the ACT scores,levels of serum IL-4 and IL-8 of the observation group were(4.32±0.42)points,(12.10±3.42)ng/L,(70.69±5.94)ng/L,while those of the control group were(3.41±0.55)points,(18.75±5.43)ng/L,(90.04±6.85)ng/L,respectively,with statistically significant differences between the two groups(P<0.05).Conclusion Long term poorly controlled asthma can be treated with glucocorticoid combined with bronchodilator,which can improve the therapeutic efficacy,ACT score and serum inflammatory index,and is worthy of application.
作者
王添
WANG Tian(Department of Infectious Disease,the Second Affiliated Hospital of Shenyang Medical College,Shenyang 110002,China)
出处
《中国现代医生》
2021年第21期90-92,共3页
China Modern Doctor
