摘要
目的:探讨复方片仔癀肝宝对乙醇代谢的影响。方法:SD雄性大鼠随机分为正常对照组、模型组、海王金樽组(阳性对照)和复方片仔癀肝宝高、中、低剂量组,每组8只。给药后0.5 h除了正常对照组,其余各组灌胃白酒。采用顶空气质联用法(HS-GC-MS)测定给酒后0.5、1、2、3、5 h大鼠血液中的乙醇浓度,运用ELISA法检测乙醇达到峰值时乙醇脱氢酶和乙醛脱氢酶的含量。结果:复方片仔癀肝宝组在不同时间点大鼠血液中的乙醇、乙醇脱氢酶和乙醛脱氢酶的浓度均低于模型组(P<0.05)。结论:复方片仔癀肝宝促进乙醇代谢,达到解酒的目的。
Objective： To observed the anti-alcoholism effect of complex prescription Pianzaihuang Ganbao （GB）. Methods： Male SD rats were divided into six groups randomly as follows： control group, model group, GB low dose group, GB middle dose group, GB high dose group and Haiwangjinzun group （HWJZ, as positive control）. After oral medication, the rats were orally administration with alcohol, except for the rats in the control group. Blood was collected after 0.5, 1, 2, 3, 5 hours drinking alcohol separately. The content of alcohol in blood were determined by HS-GC-MS, the content of ethanol dehydrogenase and acetaldehyde dehydrogenase were determined by ELISA. Results： The content of alcohol, ethanol dehydrogenase and acetaldehyde dehydrogenase in blood of the GB groups were decreased （P〈 0.05）. Contusion： The GB can promote the metabolism of alcohol to accelerate the elimination of ethanol.
作者
林珊
陈达鑫
赵锦燕
曾建伟
洪振丰
LIN Shan CHEN Da-xin ZHAO Jin-yan ZENG Jian-wei HONG Zhen-feng(The Institute of Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou350122 Fujian Provincial Laboratory of Integrated Traditional Chinese and Western Medicine, Fuzhou350122)
出处
《实用中西医结合临床》
2016年第11期1-3,共3页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金
2013年度陈可冀中西医结合发展基金(编号:CJK2013015)
福建省教育厅A类科技项目(编号:JA14163)
关键词
复方片仔癀肝宝
乙醇代谢
顶空气质联用仪
Complex prescription Pianzaihuang Ganban
Alcohol metabolism
Headspace gas chromatography-mass spectrometry
作者简介
通讯作者：洪振丰，E—mail：zfhong1953@163．com
