摘要
目的探讨原发性肝癌患者化疗后发生不良反应的危险因素。方法选取2021年5月至2024年5月在我院住院治疗的原发性肝癌患者120例作为研究对象,根据化疗术后是否出现不良反应分为发生组(n=78)与未发生组(n=42)。收集两组的临床资料,通过独立样本t检验或χ~2检验进行单因素分析,采用多因素Logistic回归分析原发性肝癌化疗后发生不良反应的危险因素。结果120例原发性肝癌患者中,发生不良反应78例,未发生不良反应42例。单因素分析显示,合并肝硬化、Child B级、巨大型肿瘤、有血管侵入、Bclc C期、碘油量、门静脉癌栓是原发性肝癌化疗后不良反应发生的影响因素;多因素Logistic回归分析结果显示,合并肝硬化(β=0.510,OR=1.666,95%CI=1.004~2.505)、Child B级(β=0.581,OR=1.789,95%CI=1.032~3.493)、Bclc C期(β=0.639,OR=1.895,95%CI=1.042~3.942)以及形成门静脉癌栓(β=0.562,OR=1.754,95%CI=1.005~2.463)是原发性肝癌患者化疗后发生不良反应的独立危险因素(P<0.05)。结论原发性肝癌化疗后不良反应发生率较高,但多数症状轻微,对症处理可缓解;合并肝硬化、Child B级、Bclc C期以及形成门静脉癌栓是原发性肝癌患者发生不良反应的独立危险因素,临床上应密切关注并实施针对性干预。
Objective To explore the risk factors of adverse reactions after chemotherapy in patients with primary liver cancer.Methods 120 primary liver cancer patients who were hospitalized in our hospital from May 2021 to May 2024 were selected as the study subjects,and were divided into the occurrence group(n=78)and the non-occurrence group(n=42)according to whether the adverse reactions occurred after chemotherapy.The clinical data of the two groups were collected,and one-way analysis was performed by independent samples t-test orχ2 test;multifactorial Logistic regression was used to analyze the risk factors for the occurrence of adverse reactions after chemotherapy for primary liver cancer.Results Among 120 patients with primary liver cancer,78 of them developed adverse reactions and 42 of them did not develop adverse reactions.Univariate analysis showed that the combination of cirrhosis,Child B grade,giant-type tumor,the presence of vascular invasion,Bclc stage C,high amount of iodine oil,and portal vein cancer thrombus were the influencing factors for the occurrence of adverse reactions after chemotherapy for primary liver cancer;and multifactorial Logistic regression analysis showed that the combination of cirrhosis(β=0.510,OR=1.666,95%CI=1.004-2.505),Child B class(β=0.581,OR=1.789,95%CI=1.032-3.493),Bclc stage C(β=0.639,OR=1.895,95%CI=1.042-3.942),and the formation of portal vein cancerous thrombus(β=0.562,OR=1.754,95%CI=1.005-2.463)were independent risk factors for adverse reactions after chemotherapy in patients with primary hepatocellular carcinoma(P<0.05).Conclusion The rate of adverse reactions after chemotherapy for primary liver cancer is high,but most of the symptoms are mild and can be relieved by symptomatic treatment;among them,the combination of cirrhosis,Child B grade,Bclc C stage,and the formation of portal vein thrombus are the independent risk factors for the occurrence of adverse reactions in patients with primary liver cancer,which need to be closely watched.
作者
叶向春
钟健平
廖声有
YE Xiangchun;ZHONG Jianping;LIAO Shengyou(Department of Oncology and Hematology,Jiangxi Anyuan County People's Hospital,Anyuan County,Jiangxi Province,342100,China;Department of Cardiothoracic and Breast Surgery,Jiangxi Anyuan County People's Hospital,Anyuan County,Jiangxi Province,342100,China)
出处
《蛇志》
2024年第4期480-483,529,共5页
Journal of Snake
基金
赣州市卫生健康委员会市级科研计划项目(项目名称:肝恶性肿瘤患者化疗毒副反应发生的危险因素评估和风险评分简表的有效性验证,项目编号:GZWJW202402343)。
