摘要
目的探讨片仔癀(PZH)对干酵母致新西兰兔发热模型的解热抗炎作用。方法新西兰兔56只,雌雄各半,随机分为7组:正常对照组、模型组、阿司匹林对照组、小柴胡颗粒剂组、PZH 0.24g·kg-1、0.12g·kg-1、0.06g·kg-1剂量组,观察灌胃给药不同剂量(0.24g·kg-1、0.12g·kg-1、0.06g·kg-1)的PZH后不同时间点的体温变化,同时观察PZH对兔血清TNFα、IL-1β、IL-8、白细胞含量的影响。结果干酵母所致发热新西兰兔模型中,片仔癀0.24g·kg-1、0.12g·kg-1剂量组与模型组比较体温显著降低(P<0.05);片仔癀0.24g·kg-1、0.12g·kg-1剂量组兔血清TNFα、IL-1β、IL-8、白细胞含量与模型组比较有显著性差异(P<0.05),且片仔癀各给药组兔血清TNFα、IL-1β、IL-8、白细胞含量的降低与药物呈剂量依赖效应。结论片仔癀具有一定的解热抗炎作用,其作用与阿司匹林相当、优于小柴胡颗粒剂。
OBJECTIVE To explore antipyretic and anti-inflammatory effects of Pien Tze Huang（ PZH） on dry yeast induced febrile response in rabbits. METHODS 42 rabbits（ half male and half female） were divided into normal group,model group,aspirin group,Xiaocaihu granule group,0. 24g·kg^-1dose of PZH group,0. 12g·kg^-1dose of PZH group and 0. 06g·kg^-1dose of PZH group. The fever model of rabbits was induced by injection of dry yeast to observe the effect of antipyretic and anti-inflammatory effects of PZH. Tempretures of different time were observed after administrating PZH（ 0. 24 g · kg^-1,0. 12g·kg^-1and 0. 06 g · kg^-1）. At the same time,the effect of PZH on levels of TNFα,IL-1β,IL-8 and leukocyte were determined. RESULTS Compared with model group,Xiaocaihu granule group,0. 24g·kg^-1dose of PZH group,0. 12g·kg^-1dose of PZH group and 0. 06 g ·kg^-1dose of PZH group obviously decrease the tempreture（ P〈0. 05）,moreover the effect of PZH is in a dose-dependent manner. Meanwhile,Xiaocaihu granule group,0. 24g·kg^-1dose of PZH group,0. 12g·kg^-1dose of PZH group and0. 06g·kg^-1dose of PZH group inhibited the generation of TNFα,IL-1β,IL-8 and leukocyte,and they were significant comparing with model group（ P〈0. 05）. The effect of PZH is also in a dose-dependent manner. CONCLUSION PZH has antipyretic and anti-inflammatory effects,it is similar to aspirin and better than Xiaocaihu granule.
出处
《海峡药学》
2015年第10期11-13,共3页
Strait Pharmaceutical Journal
基金
福建省科技厅高校产学合作重大项目(2013Y4005)
关键词
片仔癀
干酵母
解热抗炎
Pien Tze Huang
Dry yeast
Antipyretic and anti-inflammatory effects
作者简介
作者简介：黄进明，男（1966-）。学历：硕士。联系电话：13906962427
