摘要
目的探讨血脂及身体质量指数(body mass index,BMI)与结直肠息肉病理类型的相关性。方法收集2010年1月–2015年8月在首都医科大学附属北京同仁医院消化内科住院行结直肠息肉切除的246例患者,回顾性分析不同病理类型结直肠息肉与血脂及BMI的关系。结果绒毛状管状腺瘤及绒毛状腺瘤组高脂血症发生率为64.7%,高于管状腺瘤组(36.2%)、炎性息肉及增生性息肉组(45.9%)。绒毛状管状腺瘤及绒毛状腺瘤组血清甘油三脂(TG)水平(2.24±2.50)mmol/L高于管状腺瘤组[(1.29±0.96)mmol,P<0.05]、炎性息肉及增生性息肉组[(1.40±0.72)mmol/L,P<0.05],三组间血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平、BMI差异均无统计学意义(P>0.05)。有异型增生组血清TG水平(1.79±2.26)mmol/L高于非异型增生组[(1.38±0.86)mmol/L,P<0.05],BMI略高于无异型增生组[(24.45±4.34 vs 24.07±3.52)kg/m^2,P<0.05],两组血清TC、HDL及LDL水平差异均无统计学意义(P>0.05)。结论高TG血症可能与病理类型较差的结直肠息肉(如带绒毛结构的腺瘤或有异型增生的腺瘤)有关。
Objective To investigate the association of serum lipids and body mass index （BM1） with the histological pattern of colorectal polyps. Methods Two hundred and forty six patients underwent colorectal polyps resection were involved. According to pathology examination, the level of serum lipid and BMI were tested and retrospectively analyzed. Results The incidence of hyperlipidemia of villous-rich （tubulovillous/villous） adenoma group was 64.7% , which was higher than that of tubular adenoma group （36.2%） and hyperplastic/inflammatory polyps group （45.9 % ）. The levels of TG of tubulovillous/villous adenoma group （2.24 ± 2.50） mmol/L were higher than those of tubular adenoma group [ （ 1.29 ± 0.96） mmol/L, P 〈 0.05 I and hyperplastic/inflammatory polyps group [ （ 1.40 ± O. 72） mmol/L, P 〈 0.05 ]. There were no significant differences in the levels of TC, HDL-C, LDL-C and BMI（P 〉0.05）. The levels of TG of hyperpla- sia group （1.79 ± 2.26） mmol/L were higher than those of non-hyperplasia group [ （ 1.38 ± 0.86） mmol/L, P 〈 0.05 ]. The BMI of hyperplasia group was higher than that of non-hyperplasia group [ （24.45 ± 4.34 vs 24.07 ± 3.52） kg/m^2 , P 〈 0.05 ]. Conclusion High serum TG tended to have a higher risk of tubulovillous/villous colorectal adenoma or polyps with hyperplasia.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第9期1050-1053,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
北京市医管局临床医学发展专项(扬帆计划)重点医学专业发展计划项目"微创消化外科"(ZYLX201612)
作者简介
郭子皓，医师，硕士学位，研究方向：消化系统疾病内镜下诊治。E—mail：zihaoguo@139．com
通讯作者：张川，主任医师，研究方向：消化系统疾病内镜下诊治。E-mail：digeslivezhang@163.com
