摘要
结直肠癌(colorectal cancer,CRC)是常见的恶性肿瘤之一,近年在大城市的发病率不断上升,大量研究表明,超重或肥胖与CRC的发生、发展和预后有一定关联。肥胖可以增加CRC的患病风险,随着体质量指数(body mass index,BMI)、腰围或腰臀比的增加,在男性中患病风险更高,且患结肠癌比直肠癌风险更大。本文阐述了肥胖与CRC的关系,分别从肿瘤发生的可能机制,包括慢性炎症、肠道菌群失调和胰岛素及胰岛素样生长因子的异常,肥胖与结直肠腺瘤和CRC的临床研究进展及预防进行探讨,为今后的研究提供一定的依据和方向。
Colorectal cancer (CRC) is one of the malignant tumors, the incidence of which in large cities has been rising in recent years. A large number of studies have shown that overweight and obesity have relationships with the occurrence , development and prognosis of CRC. Obesity may increase the risk of CRC. The relative risk associated with increasing BMI, waist circumference or waist-to-hip ratio is higher in men and for cancer of the colon than rectum. This article described mechanisms of tumorigenesis including chronic inflammation, gut microorganisms and abnormalities in insulin and insulin-like growth factor signaling, progress of clinical research and prevention about obesity and colorectal adenoma and CRC.
作者
倪宇
徐洪雨
NI Yu;XU Hongyu(Department of Gastroenterology, the First Hospital Affiliated to Harbin Medical University, Harbin 150001, China)
出处
《胃肠病学和肝病学杂志》
CAS
2019年第5期499-502,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
肥胖
结直肠腺瘤
结直肠癌
Obesity
Colorectal adenoma
Colorectal cancer
作者简介
第一作者:倪宇,在读硕士研究生,研究方向:消化道肿瘤。E-mail:834560057@qq.com;通讯作者:徐洪雨,主任医师、博士、教授、硕士研究生导师。从事消化内科疾病的诊断与治疗,胃肠镜诊断及镜下治疗,超声内镜及超声引导下介入治疗,内窥镜下高频电相关治疗,内镜下胰胆管疾病的诊断及治疗,多次获得医院及学校优秀医务工作者、优秀教师称号。兼任黑龙江省干细胞学会理事,黑龙江省肝病学会秘书,哈尔滨消化内镜学会副主任委员,《胃肠病学和肝病学杂志》编委。在黑龙江省率先开展双气囊小肠镜诊治、超声内镜引导下胰腺假性囊肿穿刺治疗并获省卫生厅新技术一等奖。在科研方面主持卫生部课题及黑龙江省攻关重点课题三项,黑龙江省自然科学基金二项,卫生厅基金一项。获黑龙江省教委成果奖三等奖一项,黑龙江省政府科技进步奖三等奖一项。
