摘要
目的长春瑞滨是目前常用的化疗药物之一,它是缓和的发疱剂,能引起静脉炎。本研究旨在探讨外周静脉推注长春瑞滨引起静脉炎的相关因素。方法前瞻性的观察197例初治晚期非小细胞肺癌患者,化疗方案包括长春瑞滨,每一周期评估静脉炎的程度。性别、年龄、身体质量指数(BMI)、化疗药物、长春瑞滨的剂量、化疗周期为临床相关因素。结果97例患者共接受了1 098次静脉推注,67例(34.01%)发生静脉炎,身体质量指数正常者(BMI<25)静脉炎的发生率为29.25%,肥胖者(BMI≥25)为48.00%,两组比较差异有显著性(P<0.05)。其他相关因素与静脉炎的发生无关。Logistic多因素回归分析显示身体质量指数是与静脉炎发生增加有关的重要因素(P<0.05)。结论肥胖的晚期非小细胞肺癌患者给予长春瑞滨治疗时更易发生静脉脉炎,而患者性别、年龄,所用化疗药物、长春瑞滨的剂量、化疗周期与静脉炎的发生不相关。
Objective Vinorelbine is one of the most active chemotherapeutic agents.However,it is also a moderate vesicant that is well known to cause venous irritation and phlebitis.This study is to identify clinical risk factors related to the incidence of venous irritation caused by peripheral Vinorelbine infusion.Methods Medical records were used to investigate prospectively a total of 197 cases of advanced non-small cell lung cancer treated with a chemotherapeutic regimen containing Vinorelbine.Venous irritation was evaluated in every course and graded according to the National Cancer Institute Common Toxicity Criteria version 3.0.Gender,age,body mass index（BMI）,chemotherapeutic regimen,dose of Vinorelbine and chemotherapeutic cycle were used as clinical correlation factors.Results A total of 1 098 Vinorelbine infusions were administered to 197 patients,among which venous irritation occurred in 67 cases（34.01%）.The incidence of venous irritation was 29.25% in normal BMI（〈25） group and 48.00% in high BMI（25 or more） group and the difference between two groups was significant（P〈0.05）.There were no significant correlations between the incidence of venous irritation and other clinical variables besides BMI.In the multivariate analysis,BMI was also a significant independent variable that correlated with increased risk of venous irritation（P〈0.05）.Conclusion Patients with advanced non-small cell lung cancer and high BMI may tend to develop venous irritation caused by peripheral infusion of Vinorelbine.There were no significant correlations between the incidence of venous irritation and gender,age,chemotherapeutic regimen,dose of Vinorelbine,chemotherapeutic cycle.
出处
《同济大学学报（医学版）》
CAS
2009年第2期66-69,共4页
Journal of Tongji University(Medical Science)
关键词
身体质量指数
长春瑞滨
静脉炎
肺肿瘤
body mass index
Vinorelbine
venous irritation
lung cancer
作者简介
朱韧（1973-），女，主治医师，学士．E-mail：zhuren_73@126．com
