摘要
目的：评价奥硝唑、培氟沙星联合治疗慢性牙周炎的临床疗效。方法选取200例慢性牙周炎临床患者作为研究对象，随机数字表法分为观察组和对照组，观察组100例，给予奥硝唑／培氟沙星联合治疗；对照组100例采用奥硝唑治疗，治疗7 d 后观察临床疗效，并使用 ELISA 法测定血清炎症相关指标（包括：超敏 C 反应蛋白、IL-4、IL-6以及干扰素γ的浓度水平）。结果观察组探测深度、附着丧失改善情况明显较对照组好（探测深度：t ＝2．113，P ＜0．05；附着丧失：t ＝1．894，P ＜0．05），且血清炎症指标改善程度也明显优于对照组（超敏 C 反应蛋白：t ＝2．001，P ＜0．05；IL-6：t ＝1．953，P ＜0．05；干扰素-γ：t ＝1．976，P ＜0．05），治疗总有效率显著优于对照组（χ^2＝24．335，P ＜0．01）。结论奥硝唑、培氟沙星联合治疗慢性牙周炎的临床疗效明显优于奥硝唑单方治疗，值得临床推广使用。
Objective To evaluate combination therapy effects of ornidazole and pefloxacin on chronic periodontitis.Methods 200 cases of chronic periodontitis were chosen from the Stomatological Hospital of Hangzhou as study subjects.100 cases in observation group were treated with ornidazole and pefloxacin combination treatment, while another 100 cases in control group were treated with ornidazole.The treatments lasted 7 days.The effects and inflammation -related perimeters （including hs -CRP,IL -4,IL -6,IFN -γ）in patients＆#39;serum were measured. Results Probing depth,attachment loss and inflammation -related perimeters of the observation group were improved significantly,and even were much better than the control group （probing depth：t =2.113,P 〈0.05;attachment loss：t =1.894,P 〈0.05,hypersensitive C -reactive protein：t =2.001,P 〈0.05;IL -6：t =1.953,P 〈0.05;interferon -γ：t =1.976,P 〈0.05）.And the total effective rate of the observation group was also better than that of the control group （χ^2 =24.335,P 〈0.01）.Conclusion Combination treatment of ornidazole and pefloxacin is more effective than single treatment of ornidazole,which is worthy of widely promoted in clinical.
出处
《中国基层医药》
CAS
2016年第17期2676-2680,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
牙周炎
奥硝唑
培氟沙星
Periodontitis
Ornidazole
Pefloxacin
