摘要
为了有效应对西药治疗溃疡性结肠炎的局限性、易复发性,如何发挥中医药治疗溃疡性结肠炎的优势已成为当前研究的热点。近年来经方-乌梅丸加减方在临床和实验中均被广泛地有效用于溃疡性结肠炎的治疗,明其作用机理有助于乌梅丸优势的充分发挥。现主要从抗炎镇痛、调节信号通路、纠正肠道菌群失调、抗氧化、抑制肠上皮细胞凋亡、调节免疫等方面,就乌梅丸治疗UC作用机制的研究进展进行综述,旨在为进一步研究乌梅丸及其他药物治疗溃疡性结肠炎的机理提供一定的实践理论依据和参考思路。
To effectively deal with the limitations and recurrence of Western medicine in the treatment of ulcerative colitis,how to exert the advantages of traditional Chinese medicine in the treatment of ulcerative colitis has become a focus of current research.In recent years,the addition and reduction of Wumei Pill,a Chinese classic herbal formula,has been widely and effectively used in clinical and experimental treatment of ulcerative colitis,and clarifying its mechanism of action is help to the full play of the advantages of Wumei Pill.This paper summarizes the mechanism of treatment of ulcerative colitis by Wumei Pill from the aspects of anti-inflammatory and analgesic,regulating signal pathways,correcting intestinal flora disorders,anti-oxidation,inhibiting apoptosis of intestinal epithelial cells,regulating immunity,which designed to provide some practical theoretical basis and reference ideas for the study of Wumei Pill and other prescription drugs for ulcerative colitis.
作者
周步高
刘馥春
张晓云
刘端勇
ZHOU Bu-gao;LIU Fu-chun;ZHANG Xiao-yun;LIU Duan-yong(College of Science and Technology,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Graduate School,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处
《时珍国医国药》
CAS
CSCD
北大核心
2018年第11期2731-2733,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(81460679,81760808)
江西省自然科学基金(20171BAB205088,20171BAB215057)
江西省卫生厅中医药科研计划(20185510,20185511)
关键词
乌梅丸
溃疡性结肠炎
机制
综述
Wumei Pill
Ulcerative colitis
Mechanism
Review
作者简介
周步高(1978-),男(汉族),江西临川人,江西中医药大学副教授,硕士研究生导师,博士学位,主要从事中医理论教学及临床基础研究工作;通讯作者:刘端勇(1975-),男(汉族),江西南昌人,江西中医药大学教授,博士研究生导师,博士学位,主要从事中药免疫药理工作.
