摘要
目的探讨脑梗死患者血清同型半胱氨酸(homocysteine,HCY)、脂蛋白(a)[lipoprotein(a),Lp(a)]和超敏C-反应蛋白(high sensitive C-reactive protein,hs-CRP)的变化及联合检测的临床意义。方法选取183例脑梗死患者和同期健康体检者163例,分别检测样本中同型半胱氨酸、脂蛋白(a)和超敏C-反应蛋白,并进行统计学分析。使用ROC曲线确定此3项结果诊断脑梗死的界值。结果脑梗死组HCY、Lp(a)和hs-CRP分别为(16.7±6.3)μmol/L、(343.6±150.1)mg/L、(3.87±1.88)mg/L,正常对照组分别为(12.9±4.7)μmol/L、(205.4±190)mg/L、(2.45±0.69)mg/L。脑梗死组的3项检测指标均明显高于正常对照组,差异有统计学意义(P<0.05)。结论脑梗死的发生与HCY、Lp(a)和hs-CRP密切相关,可作为其危险因素。
Objective To investigate the changes and the clinical significance of joint detection of serum homocysteine（ HCY）,lipoprotein（ a） [Lp（ a） ] and high sensitive C-reactive protein（ hs-CRP） in patients with cerebral infarction. The cut of value of three results of the patients with cerebral infarction was determined by ROC curve. Methods The levels of HCY,Lp（ a）,hs-CRP were measured in 183 patients with cerebral infarction and 163 healthy controls and the results were made statistical analysis. Results The levels of Hcy,Lp（ a） and hs-CRP in patients with cerebral infarction were（ 16. 7 ± 6. 3） μmol / L,（ 343. 6 ± 150. 1） mg / L,（ 3. 87 ±1. 88） mg / L,in healthy control group were（ 12. 9 ± 4. 7） μmol / L,（ 205. 4 ± 190） mg / L,（ 2. 45 ± 0. 69） mg / L. The levels of Hcy,Lp（ a） and hs-CRP in patients with cerebral infarction were significantly higher than those in healthy controls（ P〈0. 05）. Conclusion Occurrence of cerebral infarction and Hcy,Lp（ a） and hs-CRP levels were closely correlated,so the indexes can be used as risk factors.
出处
《首都医科大学学报》
CAS
北大核心
2015年第5期782-785,共4页
Journal of Capital Medical University
作者简介
Corresponding author, E-mail ： wlqtian@ 163. com
