摘要
目的观察叶酸和维生素B12对脑梗死患者血管内皮功能及神经缺损评分的影响。方法选取2013年7月—2015年7月湖北省京山县人民医院神经内科住院治疗的脑梗死患者168例作为研究对象,随机分为观察组（n=84）和对照组（n=84）。对照组给予常规治疗;观察组在对照组治疗基础上给予叶酸和和维生素B12口服。比较2组患者血清同型半胱氨酸（Hcy）、一氧化氮（NO）、内皮素（ET）、神经功能缺损（（SS）评分和脑梗死复发率等。结果治疗后观察组血浆Hcy和ET分别为（12.02±3.82）mmol/L和（53.22±12.40）ng/L,低于对照组的（19.81±5.12）mmol/L和（81.04±13.36）ng/L（t=-11.177、-13.998,P〈0.05）,观察组NO（64.59±11.27）mmol/L高于对照组（56.29±11.32）mmol/L（t=4.762,P=0.000）;治疗后观察组/对照组CSS评分（12.16±1.46/17.30±2.20）均较治疗前（21.17±3.48/20.43±3.10）降低（t=28.694、9.432,P〈0.05）,且观察组低于对照组（t=-17.842,P=0.000）;观察组治疗后脑梗死复发率为14.29%,低于对照组的28.00%（χ^2=4.299,P=0.038）。结论叶酸和维生素B12可有效改善脑梗死患者血管内皮细胞功能和神经功能缺损,减少患者愈后复发。
Objective To investigate prevention effect of folic acid and vitamin B12 timely supplement on cerebral infarction.Methods From July 2013 to July 2015,selected 168 patients with cerebral infarction in department of Neurology of Jingshan people Hospital of Hubei Province,the patients were divided into observation group（n=84） and control group（n= 84）,the control group were given routine treatment,the observation group were given folic acid and vitamin B12 oral therapy based on the treatment in control group,The plasma homocysteine（Hcy）,nitric oxide（NO）,endothelin（ET）,Chinese stroke clinical neurological impairment rating scale（CSS） and cerebral infarction recurrence rale of two groups were compared.Results After treatment,the plasma Hcy and ET were（12.02 ±3.82） mmol/L and（53.22 ± 12.40） ng/L,lower than that of the control group（19.81 ±5.12） mmol/L and（81.04 ± 13.36） ng/L（t=- 11.177,t=- 13.998,P 0.05）,the observation group＇s NO（64.59 ± 11.27） mmol/L higher than that of the control group（56.29 ± 11.32）mmol/L（t=4.762,P=0.000）;after treatment,the observation group / control group CSS score（12.16 ± 1.46/17.30 ±2.20） were lower than those before treatment（21.17 ±3.48/20.43 ±3.10） decreased（t=28.694,9.432,P〈0.05）,and the observation group than the control group（t=17.842,P= 0.000）;the observation group treatment of cerebral infarction recurrence rate as of 14.29%,which were lower than the control groups 28.00%（χ^2=4.299,P= 0.038）.Conclusion It demonstrated that the folic acid and vitamin B12 could effectively improve the vascular endothelial function and neurological deficits in patients with cerebral infarction,and reduce the recurrence after healing.
出处
《疑难病杂志》
CAS
2016年第11期1104-1107,共4页
Chinese Journal of Difficult and Complicated Cases
基金
湖北省自然科学基金资助项目(2014FFB02007)
关键词
叶酸
维生素B12
脑梗死
血管内皮功能
CSS评分
Folic acid
Vitamin B12
Cerebral infarction
Vascular endothelial function
CSS scores
作者简介
通信作者：陈贞文，E—mail：2734763835@qq．com
