摘要
[目的]研究齿叶白鹃梅叶中分离得到的黄酮类化合物对α-葡萄糖苷酶的抑制作用。[方法]以96微孔板法测定α-葡萄糖苷酶抑制作用。[结果]齿叶白鹃梅叶中多个黄酮类化合物具有α-葡萄糖苷酶抑制活性,其中木犀草素,木犀草素-7-O-β-D-新橙皮糖苷,芹菜素,芹菜素-7-O-β-D-新橙皮糖苷,槲皮素,槲皮素-3-O-β-D-葡萄糖苷对α-葡萄糖苷酶的抑制活性高于阿卡波糖。[结论]黄酮类化合物可能是齿叶白鹃梅叶具有降糖作用的物质基础。
[Objective] To investigate the inhibitory activity of flavonoids isolated from Exochorda serratifolia S.Moore. leaves on α-glucosidase.[Methods] Inhibitory activity of α-glucosidase was screened by the 96-microplatebased method.[Results] The flavonoids showed inhibitory activity on α-glucosidase. Among them, luteolin, luteolin-7-O-β-D-neospheroside, apigenin, apigenin-7-O-β-D-neospheroside, quercetin, quercetin-3-O-β-D-glucoside showed stronger inhibitory activity than acarbose.[Conclusion] Flavonoids may be the substances basis of Exochorda serratifolia S. Moore. leaves with inhibitory activity of α-glucosidase.
出处
《天津中医药大学学报》
CAS
2015年第3期165-168,共4页
Journal of Tianjin University of Traditional Chinese Medicine
基金
国家自然科学基金项目(81202919)
关键词
齿叶白鹃梅叶
黄酮
Α-葡萄糖苷酶
抑制活性
Exochorda serratifolia S.Moore.
flavonoids
α-glucosidase
inhibitory activity
作者简介
李古月（1984-），女，药师，从事临床制剂指导工作。
