摘要
目的探讨内蒙赤峰地区蒙古族非酒精性脂肪肝患者血清抵抗素水平与胰岛素抵抗及其他危险因素的关系。方法蒙古族非酒精性脂肪肝患者100例为观察组,体检健康者30例为对照组,采用ELISA方法测定2组空腹血清抵抗素水平,测量身高、体质量、腰围、臀围等,测定血糖、血脂、肝功能及胰岛素水平,并计算体质量指数、腰臀比和胰岛素敏感指数。结果观察组血清抵抗素为(24.40±3.20)μg/L,对照组为(15.74±2.04)μg/L,2组比较差异有统计学意义(P<0.01);相关性分析显示血清抵抗素与体质量指数(r=0.156,P=0.038)、腰臀比(r=0.059,P=0.041)、三酰甘油(r=0.167,P=0.049)、空腹胰岛素(r=0.224,P=0.042)呈正相关,与胰岛素敏感指数呈负相关(r=-0.104,P=0.008)。结论内蒙赤峰地区蒙古族非酒精性脂肪肝患者血清抵抗素水平高于健康人,非酒精性脂肪肝性肝病患者血清抵抗素可促进脂肪肝炎症的发生。
Objective To investigate the relationship of serum resistin level with insulin resistance and other risk factors in patients with non-alcoholic fatty liver disease in Chifeng,Inner Mongolia.Methods One hundred Mongolian patients with non-alcoholic fatty liver（observation group）and 30 healthy volunteers（control group）were measured the height,body mass,waist circumference and hip circumference.The plasma glucose,lipid,liver function and insulin levels were detected by ELISA,and body mass index,waist-to-hip ratio and insulin sensitivity index were calculated.Results There was a significant difference in the serum resistin level between observation group（（24.40±3.20）μg/L）and control group（（15.74±2.04）μg/L）（P〈0.01）.Correlation analysis showed that serum resistin was positively correlated with body mass index（r=0.156,P=0.038）,waist-to-hip ratio（r=0.059,P=0.041）,triacylglycerol（r=0.167,P=0.049）and fasting insulin（r=0.224,P=0.042）,and negatively correlated with insulin sensitivity index（r=-0.104,P=0.008）.Conclusion The patients with non-alcoholic fatty liver disease have higher serum resistin level than healthy people in Chifeng,Inner Mongolia,which would promote the development of fat hepatitis disease.
出处
《中华实用诊断与治疗杂志》
2015年第4期372-374,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
内蒙古教育厅自然科学基金项目(NJ10242)
关键词
非酒精性脂肪肝
抵抗素
胰岛素抵抗
Non-alcoholic fatty liver disease
resistin
insulin resistance
