摘要
目的:研究非酒精性脂肪肝患者血清脂联素水平与胰岛素抵抗程度及血清铁代谢的相关性。方法:选择非酒精性脂肪肝患者35例和健康体检者56例为研究对象,测定体重指数(BMI),检测空腹血糖(FBG)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、糖化血红蛋白(HbA1C)、尿酸(UA)、尿微量白蛋白/尿肌酐(UAlb/Ucr)值等生化指标,并行肝脏B超检查。放射免疫法测定空腹胰岛素(FINS),计算胰岛素抵抗指数(HOMA IR);同时测定血清铁(SI)、铁蛋白(SF)、转铁蛋白(TRF)、血清脂联素水平。结果:(1)非酒精性脂肪肝组BMI、TC、TG、FBG、HOMAIR、UAlb/Ucr、SF均高于对照组,血清脂联素水平低于对照组。(2)相关性研究表明,血清脂联素与SF、FINS、HDL呈正相关,与FBG、HbA1C、HOMA IR、TC、LDL呈负相关。结论:非酒精性脂肪肝患者血清脂联素下降,血清脂联素水平与胰岛素抵抗指数呈负相关,与铁蛋白呈正相关。
Objective：To investigate the relationships among adiponectin,ferritin metabolism and insulin resistance in patients with nonalcohlic fatty liver disease（NAFLD）.Methods：Thirty-five patients with NAFLD and 56 healthy controls were studied.Abdominal ultrasound was taken for fatty liver examination.Serum ferritin,insulin levels and adiponectin were determined by radioimmunoassay（RIA）.Insulin resistance indexe was assessed by the homeostasis assessment-insulin resistance（HOMA-IR）.Other biochemical variables were measured by routine methods.Results：（1） Compared with healthy controls,BMI,TC,TG,FBG,HOMA IR,Ualb/Ucr,SF were significantly increased in NAFLD patient while adiponectin was significantly decreased.（2） FBG,HbA1C,HOMA IR,TC,LDL were negative related with adiponectin,while SF、FINS、HDL were closed related with it.Conclusions：Adiponectin is significantly decreased in patients with NAFLD.Adiponectin is negative related with insulin resistance and is closed related with SF.
出处
《东南大学学报（医学版）》
CAS
2010年第3期322-325,共4页
Journal of Southeast University(Medical Science Edition)
基金
南京市白下区科技项目(编号08102)
关键词
非酒精性脂肪肝
脂联素
铁蛋白
胰岛素抵抗
non-alcoholic fatty liver disease
adiponectin
serum ferrin
insulin resistance
作者简介
李琪（1976-），女，江苏常州人，主治医师。E-mail：lgme@263．net[通讯作者]王晓峰E-mail：xfw126@yahoo．com．cn
